Paper Details

  1. Home
  2. Paper Details

Effects of zileuton, a new 5-lipoxygenase inhibitor, in experimentally induced colitis in rats.

Author: CameriniR, CaputiA P, GrazianiP, SquadritoF, ZingarelliB

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.

Overview

Zileuton, a 5-lipoxygenase inhibitor, was compared to sulphasalazine in an experimental model of rat colitis. Zileuton was more effective than sulphasalazine in reducing colonic leukotriene levels, inflammation, and tissue damage, suggesting its potential benefit in treating inflammatory bowel diseases.
Paper Details　
Original Abstract of the Article :
The efficacy of zileuton, a new 5-lipoxygenase inhibitor, was investigated in comparison with sulphasalazine in an experimental model of rat colitis. Under light anaesthesia with ether, male rats were subjected to intracolonic administration of trinitrobenzene sulfonic acid (TNB) in 50% ethanol and ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1007/BF01998968

データ提供：米国国立医学図書館（NLM）

Zileuton: A Promising New Treatment for Colitis

Colitis, a debilitating inflammatory bowel disease, is often difficult to treat. This research explores the efficacy of zileuton, a novel 5-lipoxygenase inhibitor, in an experimental model of colitis in rats. The study compares the effects of zileuton to sulfasalazine, a commonly used colitis treatment. The findings demonstrate that zileuton significantly reduces colonic inflammation and damage in the experimental colitis model, suggesting its potential as a new therapeutic agent for colitis.

Zileuton: A New Hope for Colitis Treatment

This research offers a glimmer of hope for patients with colitis, demonstrating the effectiveness of zileuton in reducing inflammation and damage in an experimental model. The study suggests that zileuton may offer a valuable alternative to existing treatments, potentially providing a more effective and well-tolerated option for patients with colitis.

Living with Colitis: Exploring New Treatment Options

Colitis can significantly impact quality of life. This research highlights the potential of zileuton as a promising new treatment option. By exploring novel therapies, we can expand our arsenal of tools for combating colitis and providing patients with more effective and personalized treatment approaches.

Dr.Camel's Conclusion

Just as a camel adapts to its harsh desert environment, colitis patients must learn to navigate the challenges of this chronic condition. This research suggests that zileuton may offer a new and effective way to combat the inflammation and damage associated with colitis, providing a potential oasis of relief for these patients.

Date :
  1. Date Completed 1994-03-07
  2. Date Revised 2019-08-25
Further Info :

Pubmed ID

7905704

DOI: Digital Object Identifier

10.1007/BF01998968

Related Literature

Article Analysis
・Effects of zileuton
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.