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The efficacy, as modified by the circadian rhythm of salbutamol administered by different routes.

Author: AlankoK, LahdensuoA

Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.

Overview

Salbutamol, administered by different routes, effectively improved peak expiratory flow rate (PEFR) in asthmatic patients. The tablet and combination therapy (tablet and aerosol) were superior to aerosol treatment alone. Salbutamol demonstrated a clear-cut circadian rhythm in bronchodilator response, with less pronounced effects at night and in the early morning.
Paper Details　
Original Abstract of the Article :
Fourteen asthmatic outpatients participated in a total of 16 trials with salbutamol administered by different routes. Drug dosage was one 4-mg tablet, of two inhalations of 100 mug of salbutamol aerosol or a combination of both, four times daily. During the trial the patients measured their peak exp...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/792993

データ提供：米国国立医学図書館（NLM）

Timing is Everything: The Rhythmic Effects of Salbutamol

The treatment of [asthma] is an ongoing quest, and this research examines the impact of [circadian rhythms] on the effectiveness of [salbutamol]. Imagine the human body as a desert oasis, with its rhythms and cycles influencing the effectiveness of treatments. This study explores the interplay between timing and the therapeutic response to salbutamol, exploring different routes of administration and their impact on asthma management.

A Rhythmic Response to Salbutamol

The study demonstrates a clear-cut circadian rhythm in bronchial obstruction, comparing it to the ebb and flow of the desert's heat. The effectiveness of salbutamol varies throughout the day, with the highest response observed at specific times, particularly at 10:00 AM and 9:30 PM. The research suggests that the timing of administration can significantly impact the effectiveness of this medication, highlighting the importance of considering the body's natural rhythms in treatment strategies.

A Personalized Approach to Asthma Management

This study emphasizes the need for a personalized approach to asthma management, taking into account individual circadian rhythms and the optimal time for medication administration. This research offers valuable insights into the intricate interplay between timing, medication delivery, and therapeutic response, demonstrating that a better understanding of the body's natural cycles can lead to improved asthma management.

Dr.Camel's Conclusion

This research is like a sundial, revealing the importance of timing in asthma management. By understanding the rhythmic response of the body to salbutamol, healthcare providers can personalize treatment strategies, leading to improved symptom control and overall well-being for patients.

Date :
  1. Date Completed 1977-01-25
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

792993

DOI: Digital Object Identifier

792993

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Languages

English

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