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Combination chemotherapy, glucocorticoids, and interferon alfa in the treatment of multiple myeloma: a Southwest Oncology Group study.

Author: BarlogieB, CrowleyJ J, FinleyP, GroganT M, PughR P, SalmonS E

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Higher-dose glucocorticoids were associated with higher response rates and improved survival in multiple myeloma patients. Interferon maintenance did not improve survival.
Paper Details　
Original Abstract of the Article :
PURPOSE: Standard therapy for multiple myeloma consists of cytotoxic chemotherapy plus glucocorticoids. Interferon (IFN) alfa maintenance is reported to prolong chemotherapy-induced remissions and survival. This study evaluates induction chemotherapy, glucocorticoids, and interferon maintenance in m...See full text at original site
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引用元：
https://doi.org/10.1200/JCO.1994.12.11.2405

データ提供：米国国立医学図書館（NLM）

Multiple Myeloma: Exploring Treatment Options in the Desert of Cancer

Multiple myeloma, a cancer of plasma cells in the bone marrow, presents a challenging landscape for clinicians. This study investigates the effectiveness of various chemotherapy regimens, including combinations of cytotoxic drugs and glucocorticoids, in treating this complex disease. The researchers also explored the role of interferon alfa maintenance in prolonging remissions and improving survival outcomes.

Chemotherapy and Interferon Alfa: Navigating the Dunes of Multiple Myeloma Treatment

The study found that chemotherapy regimens with higher doses of glucocorticoids led to higher response rates and improved survival in patients with multiple myeloma. However, the addition of interferon alfa maintenance, while initially thought to be beneficial, did not significantly prolong relapse-free or overall survival in this particular study. These findings highlight the ongoing search for optimal treatment strategies for this challenging cancer.

The Importance of Individualized Treatment: Tailoring Care in the Desert of Cancer

This study underscores the importance of individualizing treatment plans for patients with multiple myeloma. The optimal combination of chemotherapy, glucocorticoids, and other supportive therapies must be carefully considered for each patient based on their specific characteristics and disease stage. Ongoing research continues to explore new approaches to treating this complex cancer.

Dr.Camel's Conclusion

This study offers valuable insights into the complexities of treating multiple myeloma. While high-dose glucocorticoids have proven beneficial, the role of interferon alfa maintenance remains unclear. The study highlights the need for personalized treatment plans that are tailored to each patient's specific needs, emphasizing the ongoing journey towards more effective and personalized therapies for this challenging cancer.

Date :
  1. Date Completed 1994-12-02
  2. Date Revised 2022-03-10
Further Info :

Pubmed ID

7964957

DOI: Digital Object Identifier

10.1200/JCO.1994.12.11.2405

Related Literature

Article Analysis
・Effective treatment of multiple myeloma
SNS
PICO Info
in preparation
Languages

English

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