Retinal toxicity of high dose intravitreal ganciclovir.

Author: MaguireA M, SaranB R

Paper Details 
Original Abstract of the Article :
Intravitreal administration of ganciclovir has been used to treat cytomegalovirus (CMV) retinitis in patients with acquired immune deficiency syndrome (AIDS) who are unable to tolerate systemic antiviral therapy. Although retinal toxicity from intravitreal ganciclovir has been observed in animal exp...See full text at original site
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引用元:
https://doi.org/10.1097/00006982-199414030-00010

データ提供:米国国立医学図書館(NLM)

Ganciclovir: A Powerful Antiviral with Potential for Retinal Toxicity

The treatment of [cytomegalovirus (CMV) retinitis] in patients with AIDS has benefited from the development of antiviral medications like ganciclovir. However, like all medications, ganciclovir can have side effects. This article discusses the potential for [retinal toxicity] from intravitreal administration of ganciclovir, a route of administration used to treat CMV retinitis in patients unable to tolerate systemic antiviral therapy. While retinal toxicity from intravitreal ganciclovir has been observed in animal studies, this article notes that retinal toxicity has not been reported in humans.

Ganciclovir: Balancing Benefits and Risks

The article highlights the potential for retinal toxicity with intravitreal ganciclovir administration, although clinical evidence in humans is limited. This underscores the importance of careful patient monitoring, particularly those receiving intravitreal ganciclovir, to identify any early signs of retinal toxicity. Early detection and intervention can help minimize potential complications and ensure the safety of this valuable antiviral treatment.

Navigating the Terrain of Antiviral Treatment: A Balancing Act

Just as a camel navigates the terrain of a desert, we must carefully navigate the complex landscape of antiviral treatment. This article reminds us that even seemingly effective medications can have potential side effects. It is crucial to weigh the benefits of treatment against the potential risks and to monitor patients closely for any adverse effects. Open communication between patients and healthcare providers is essential for managing treatment effectively and ensuring the best possible outcomes.

Dr.Camel's Conclusion

The desert of antiviral treatment can be a place of both healing and potential harm. This article serves as a reminder that vigilance is key in managing antiviral therapy, particularly with medications like ganciclovir that can have potential side effects. By understanding the risks and benefits, and by monitoring patients closely, we can strive to create a safer and more effective treatment landscape for those battling viral infections.

Date :
  1. Date Completed 1994-12-22
  2. Date Revised 2019-09-04
Further Info :

Pubmed ID

7973120

DOI: Digital Object Identifier

10.1097/00006982-199414030-00010

Related Literature

SNS
PICO Info
in preparation
Languages

English

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