Clonidine and lidocaine inhibition of isoflurane-induced tachycardia in humans.

Author: NambaH, NamikiA, TanakaS, TsuchidaH

Paper Details 
Original Abstract of the Article :
A rapid increase in isoflurane concentration can induce tachycardia and hypertension and increase plasma catecholamine concentrations. To investigate a possible mechanism, we measured hemodynamic responses to isoflurane administered via mask; we also administered clonidine for premedication, lidocai...See full text at original site
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引用元:
https://doi.org/10.1097/00000542-199412000-00007

データ提供:米国国立医学図書館(NLM)

Isoflurane-Induced Tachycardia: A Complex Dance of Chemicals

In the world of anesthesia, we navigate a delicate balance of chemicals to induce a state of controlled unconsciousness. Isoflurane, a commonly used anesthetic agent, can sometimes trigger an unwanted side effect: tachycardia, or a rapid heartbeat. This research investigates this phenomenon, examining the interplay of various drugs on the cardiovascular system.

Researchers administered isoflurane via a mask to their subjects and carefully monitored their hemodynamic responses. They then explored the effects of different medications, including clonidine, lidocaine, and intravenous lidocaine, on these responses. The results reveal a complex interplay of chemicals, with each drug influencing the hemodynamic response in unique ways.

Understanding the Chemical Symphony: A Key to Better Anesthesia

This study provides valuable insight into the mechanisms underlying isoflurane-induced tachycardia. Think of it like a complex musical composition with each drug acting as a different instrument. By understanding how these instruments interact, we can fine-tune our approach to anesthesia, ensuring a smoother and safer experience for our patients.

A Safer Journey: Navigating the Anesthetic Desert

This research highlights the importance of carefully considering the potential side effects of anesthetic agents and the role of various medications in mitigating these effects. It reminds us that the journey through the anesthetic desert requires meticulous planning and a deep understanding of the terrain we are navigating.

Dr.Camel's Conclusion

This research delves into the complex interplay of chemicals during anesthesia, revealing the underlying mechanisms of isoflurane-induced tachycardia. By understanding these dynamics, we can strive for safer and more efficient anesthetic practices, ensuring a smooth and comfortable journey for our patients through the desert of anesthesia.

Date :
  1. Date Completed 1995-01-10
  2. Date Revised 2019-06-28
Further Info :

Pubmed ID

7992901

DOI: Digital Object Identifier

10.1097/00000542-199412000-00007

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PICO Info
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Languages

English

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