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A novel therapeutic approach to psoriasis with combination calcipotriol ointment and very low-dose cyclosporine: results of a multicenter placebo-controlled study.

Author: AmblardP, BelaichS, ClaudyA, GrossmanR M, GuilhouJ J, SouteyrandP, ThivoletJ, ThomasP, de BelilovskyC, de la BrassinneM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Calcipotriol/cyclosporine combination therapy was more effective than placebo/cyclosporine in treating severe plaque psoriasis.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Recent advances in the treatment of psoriasis include both the topical vitamin D analogue calcipotriol and cyclosporine. Combined treatments have been sought to decrease the incidence of side effects while maintaining efficacy in the treatment of severe chronic plaque psoriasis. OBJECTI...See full text at original site
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引用元：
https://doi.org/10.1016/s0190-9622(94)70138-5

データ提供：米国国立医学図書館（NLM）

A Novel Approach to Psoriasis: Calcipotriol and Cyclosporine

The quest for effective and safe treatments for psoriasis, a chronic inflammatory skin condition, is ongoing. This study presents a novel combination therapy utilizing calcipotriol ointment, a topical vitamin D analogue, and very low-dose cyclosporine, an immunosuppressant. Researchers conducted a double-blind, placebo-controlled study to evaluate the efficacy and safety of this combination in managing severe plaque psoriasis. The results offer insights into the potential benefits and risks of this approach.

Calcipotriol and Cyclosporine: A Promising Combination for Psoriasis

The study demonstrated that the combination of calcipotriol ointment and low-dose cyclosporine was significantly more effective than placebo in achieving a complete clearing or substantial improvement in psoriasis symptoms. This suggests that this combination therapy may offer a valuable alternative for individuals with severe plaque psoriasis. Importantly, the study found no significant difference in side effects between the two treatment groups, suggesting that this combination may be a safer option than higher doses of cyclosporine alone.

Health Implications and Daily Considerations

This study offers a promising avenue for the treatment of psoriasis, highlighting the potential benefits of combining calcipotriol ointment and low-dose cyclosporine. However, further studies are necessary to establish the long-term efficacy and safety of this combination therapy. Individuals with psoriasis should consult with their dermatologist to discuss the most appropriate treatment options, taking into account individual needs and risk factors.

Dr.Camel's Conclusion

Just as a camel adapts to the harsh desert climate, researchers are constantly seeking new ways to adapt and improve treatments for chronic conditions like psoriasis. This study unveils the potential of a novel combination therapy, offering a promising solution for individuals struggling with severe plaque psoriasis. Further research will be crucial to refine this approach and ensure its long-term efficacy and safety.

Date :
  1. Date Completed 1994-07-29
  2. Date Revised 2019-07-09
Further Info :

Pubmed ID

8021375

DOI: Digital Object Identifier

10.1016/s0190-9622(94)70138-5

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Article Analysis
・Effective treatment of psoriasis
SNS
PICO Info
in preparation
Languages

English

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