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Nasal formulations of ketorolac tromethamine: technological evaluation--bioavailability and tolerability in rabbits.
Author: BottoniG, CanaliS, PeanoS, RivoltaR, SantusG, TestaB
Original Abstract of the Article :
This paper describes the development of a novel formulation of the powerful non narcotic analgesic ketorolac tromethamine. This drug is given orally three to four times/day to deliver a total of 30 to 60 mg of drug. Higher doses cannot be given orally because of gastrointestinal side effects and int...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://pubmed.ncbi.nlm.nih.gov/8135994
データ提供:米国国立医学図書館(NLM)
Nasal Delivery of Ketorolac: A Novel Approach to Pain Management
Pain management is a crucial aspect of healthcare, and the search for effective and convenient pain relief methods is ongoing. This study explores the potential of nasal delivery for ketorolac tromethamine, a potent non-narcotic analgesic. The researchers developed a novel nasal formulation of ketorolac and evaluated its bioavailability and tolerability in rabbits. They found that the nasal formulation achieved high blood levels of ketorolac, comparable to those obtained with repeated intramuscular injections, with good tolerability.
Nasal Delivery: A Convenient and Effective Route for Ketorolac
The study's findings suggest that nasal delivery of ketorolac offers a promising alternative to oral and intramuscular administration, providing a convenient and effective route for pain management. It's like finding a hidden oasis in the desert, offering a refreshing and revitalizing source of relief.
Pain Management: A Personalized Approach
This research highlights the importance of considering various administration routes for pain management, tailoring treatment to individual patient needs and preferences. Nasal delivery may be particularly advantageous for patients who prefer to avoid oral medications or injections. It's like selecting the most suitable camel for a journey through the desert, considering factors such as speed, endurance, and temperament.
Dr. Camel's Conclusion
This study demonstrates the potential of nasal delivery as a viable and effective route for administering ketorolac tromethamine, a potent non-narcotic analgesic. This innovative approach may offer a more convenient and tolerable option for pain management, potentially improving patient compliance and overall treatment outcomes.
Date :
- Date Completed 1994-04-28
- Date Revised 2013-11-21
Related Literature
English
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