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Comparison of an ephedrine/caffeine combination and dexfenfluramine in the treatment of obesity. A double-blind multi-centre trial in general practice.

Author: AhlstrømF, BreumL, Frimodt-MøllerJ, PedersenJ K

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Overview

This study compared the efficacy and safety of dexfenfluramine and ephedrine/caffeine in promoting weight loss in obese patients.
Paper Details　
Original Abstract of the Article :
In previous separate studies, dexfenfluramine (DF) and ephedrine/caffeine (EC) have been shown to promote weight loss in obese patients as compared with placebo. In order to compare the efficacy and safety of these two anorectic drugs, 103 patients with 20-80% overweight were included in a 15-week d...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/8148931

データ提供：米国国立医学図書館（NLM）

Ephedrine/Caffeine and Dexfenfluramine: A Comparative Study in the Desert of Obesity Research

The vast desert of obesity research is constantly searching for effective weight-loss strategies. This study compares two anorectic drugs, ephedrine/caffeine and dexfenfluramine, evaluating their efficacy and safety in promoting weight loss in obese patients. It's like exploring two different pathways through the desert, seeking the most effective route to a healthier weight.

A Comparative Journey Through the Desert of Obesity

The study reveals that both ephedrine/caffeine and dexfenfluramine resulted in significant weight loss, with ephedrine/caffeine showing a slightly greater effect, particularly in patients with a BMI of 30 kg/m2 or higher. It's like finding two oases, both offering relief from the weight of obesity, but one oasis proving slightly more effective for a specific group of travelers. However, both medications also had side effects, with central nervous system side effects more pronounced in the ephedrine/caffeine group, and gastrointestinal symptoms more common in the dexfenfluramine group. This is like encountering both thorny bushes and hidden scorpions along each path, reminding us that no journey through the desert is without its challenges.

Navigating the Desert of Weight Loss

This study highlights the need for a personalized approach to weight loss, considering both the potential benefits and risks of different medications. It's like choosing the right path through the desert, carefully weighing the pros and cons of each route. Further research is crucial to refine treatment strategies and minimize the side effects associated with weight-loss medications.

Dr.Camel's Conclusion

This study offers valuable insights into the comparative efficacy and safety of two anorectic drugs, emphasizing the need for a personalized approach to weight loss. It's a reminder that the desert of obesity research is constantly evolving, with new discoveries and challenges emerging as we seek to find the most effective and safe path toward a healthier weight.

Date :
  1. Date Completed 1994-05-12
  2. Date Revised 2014-06-03
Further Info :

Pubmed ID

8148931

DOI: Digital Object Identifier

8148931

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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