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Characterization of a simple animal model for nonsteroidal anti-inflammatory drug induced antral ulcer.

Author: McKnightG W, WallaceJ L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Subcutaneous administration of indomethacin to rabbits effectively models NSAID-induced antral ulceration. Indomethacin produced antral ulcers that resemble the clinically relevant type of damage seen in humans. Misoprostol, but not ranitidine, effectively reduced the severity of indomethacin-induced ulceration.
Paper Details　
Original Abstract of the Article :
Most animal models of nonsteroidal anti-inflammatory drug (NSAID) induced gastric injury are characterized by acute, superficial erosions in the corpus region, whereas the clinically significant injury in man is the deep, antral ulcer. The purpose of this study was to characterize a model of NSAID-i...See full text at original site
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引用元：
https://doi.org/10.1139/y93-066

データ提供：米国国立医学図書館（NLM）

A Novel Animal Model for Nonsteroidal Anti-inflammatory Drug (NSAID)-Induced Antral Ulceration

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain relief but can also cause gastric ulcers. This study aims to characterize a simple and reproducible animal model for NSAID-induced antral ulceration, a type of ulcer that closely resembles the damage observed in humans. The researchers administered indomethacin subcutaneously to rabbits and observed the development of antral ulcers. The study demonstrates the effectiveness of this model in mimicking human NSAID-induced antral ulceration, providing a valuable tool for future research into this condition.

A More Realistic Model for Studying NSAID-Induced Antral Ulceration

The study's development of a new animal model that accurately reflects human NSAID-induced antral ulceration is a significant advancement in research. This model will enable scientists to better understand the mechanisms underlying these ulcers and develop more effective preventative and treatment strategies.

Navigating the Desert of Gastric Ulcers

The desert of gastric ulcers can be a painful and debilitating experience. This study, like a skilled navigator, provides a new tool for exploring the complexities of these ulcers, potentially leading to improved treatments and preventative measures.

Dr.Camel's Conclusion

This study's development of a new animal model for NSAID-induced antral ulceration is a valuable contribution to research. The model's realism and reproducibility will enable scientists to more effectively study the mechanisms of these ulcers, leading to better treatments and preventive strategies. This research, like a well-charted path through the desert, guides us towards a deeper understanding of this common and often painful condition.

Date :
  1. Date Completed 1993-12-23
  2. Date Revised 2019-07-20
Further Info :

Pubmed ID

8242479

DOI: Digital Object Identifier

10.1139/y93-066

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Languages

English

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