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Clinical efficacy and side effects of acitretin on the disorders of keratinization: a one-year study.

Author: KullavanijayaP, KulthananK

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Acitretin is effective for disorders of keratinization but is associated with asymptomatic skeletal changes. In a study of 20 patients, acitretin showed clinical efficacy with minimal side effects. However, skeletal changes, primarily disc space narrowing, were observed in 12 of 18 evaluated patients.
Paper Details　
Original Abstract of the Article :
Acitretin, Ro 10-1670, the principal and free acid metabolite of etretinate, was used to treat twenty patients with disorders of keratinization. An open, prospective study of clinical efficacy, tolerability, and the effects of acitretin on lipid metabolism, hepatic function, and the osteoarticular s...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1111/j.1346-8138.1993.tb01329.x

データ提供：米国国立医学図書館（NLM）

Clinical Efficacy and Side Effects of Acitretin on the Disorders of Keratinization

The study of dermatology is a fascinating journey through the complexities of skin conditions. This study investigates the efficacy and safety of acitretin, a medication used to treat disorders of keratinization, a group of skin conditions characterized by abnormal keratin production. The researchers conducted a prospective study of 20 patients with disorders of keratinization, monitoring their response to acitretin over a one-year period.

The study found that acitretin was effective in improving symptoms of disorders of keratinization, with mild mucocutaneous side effects and asymptomatic osteoarticular changes. These findings suggest that acitretin could be a valuable treatment option for patients with these conditions, but careful monitoring for potential side effects is crucial.

Acitretin: A Promising Treatment for Disorders of Keratinization

This study provides evidence for the effectiveness of acitretin in treating disorders of keratinization. It's like finding a hidden oasis in the desert of skin conditions, offering a source of relief and symptom management.

Managing Disorders of Keratinization

If you are struggling with a disorder of keratinization, consult with a dermatologist to discuss the most appropriate treatment options. Remember, like the desert, your skin journey is unique, and it's essential to seek professional guidance to find the right path.

Dr. Camel's Conclusion

This study sheds light on the potential benefits and risks of acitretin for treating disorders of keratinization. It's a reminder that even in the vast and complex desert of dermatology, there are hidden treasures of knowledge and treatment options waiting to be discovered.

Date :
  1. Date Completed 1994-01-06
  2. Date Revised 2019-08-25
Further Info :

Pubmed ID

8245313

DOI: Digital Object Identifier

10.1111/j.1346-8138.1993.tb01329.x

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・Side Effects of acitretin
SNS
PICO Info
in preparation
Languages

English

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