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Effects of magnesium-aluminum hydroxide antacid on absorption of rufloxacin.

Author: BargiggiaS, Bianchi PorroG, BroccaliG, Dal BoL, ImbimboB P, LazzaroniM, SangalettiO

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Antacids containing magnesium and aluminum salts reduced rufloxacin absorption. Administration within 5 minutes of rufloxacin decreased absorption by 36%, while administration 4 hours later had a minor effect.
Paper Details　
Original Abstract of the Article :
The present study was designed to determine the effects of an antacid suspension containing magnesium hydroxide and aluminum hydroxide (30 ml of Maalox) on the oral bioavailability of rufloxacin (400 mg). Rufloxacin was administered orally to 12 healthy volunteers according to a randomized, balanced...See full text at original site
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引用元：
https://doi.org/10.1128/AAC.37.10.2212

データ提供：米国国立医学図書館（NLM）

Antacids: A Hidden Oasis for Rufloxacin Absorption

Rulofloxacin is an antibiotic often used to treat various infections. This study investigates the potential impact of antacids on the absorption of rufloxacin. The researchers administered rufloxacin alone and in combination with a magnesium-aluminum hydroxide antacid to healthy volunteers and monitored the levels of rufloxacin in their blood. They discovered that antacids significantly reduced the absorption of rufloxacin, especially when taken close in time to the antibiotic.

Antacids and Rufloxacin: A Delicate Dance of Absorption

The study's findings highlight the importance of timing when taking antacids and rufloxacin. Taking antacids shortly before or after rufloxacin significantly reduced the antibiotic's absorption, potentially impairing its effectiveness.

Navigating Antibiotic Treatment: A Guide for Patients

If you are prescribed rufloxacin, it's crucial to discuss the potential interactions with antacids with your doctor. They can advise you on the appropriate timing for taking these medications to ensure that the antibiotic is absorbed effectively and can work its magic.

Dr. Camel's Conclusion

Antibiotics are essential for fighting infections, but sometimes, seemingly harmless medications like antacids can interfere with their effectiveness. This study reminds us of the delicate balance in medication interactions, urging us to be mindful of potential conflicts and to seek guidance from healthcare professionals to ensure optimal treatment outcomes.

Date :
  1. Date Completed 1994-01-13
  2. Date Revised 2021-05-26
Further Info :

Pubmed ID

8257146

DOI: Digital Object Identifier

10.1128/AAC.37.10.2212

Related Literature

Article Analysis
・Effects of aluminum hydroxide
SNS
PICO Info
in preparation
Languages

English

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