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Clinical and laboratory adverse effects associated with long-term, low-dose isotretinoin: incidence and risk factors. The Isotretinoin-Basal Cell Carcinomas Study Group.

Author: AdrianzaE, EdwardsB K, HartmanA M, HelselW E, PeckG L, TangreaJ A, TaylorP R

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Isotretinoin (10 mg/day) for 3 years significantly increases the incidence of mucocutaneous effects and serum triglyceride elevations, with male gender, very fair skin, and elevated pretreatment triglyceride levels as risk factors.
Paper Details　
Original Abstract of the Article :
Adverse effects associated with the long-term low-dose regimens of retinoids used in cancer chemoprevention studies are not well described. In order to examine the clinical and laboratory adverse effects of 3 years of intervention with isotretinoin (10 mg/day) and to assess potential risk factors fo...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://pubmed.ncbi.nlm.nih.gov/8348061

データ提供：米国国立医学図書館（NLM）

The Long-Term Effects of Isotretinoin: A Randomized Trial

The [dermatology] world is always seeking safe and effective treatments for [skin conditions]. This study, like a camel navigating a sand dune, explored the potential long-term effects of isotretinoin, a medication used to treat [acne] and other skin conditions. The researchers, like explorers mapping the terrain, conducted a randomized, placebo-controlled trial to examine the clinical and laboratory adverse effects of 3 years of intervention with isotretinoin (10 mg/day) in patients who had a history of [basal cell carcinoma]. They discovered that long-term use of isotretinoin was associated with a higher incidence of [mucocutaneous effects] and [serum triglyceride elevations], particularly in males with fair skin and elevated pretreatment triglyceride levels.

Weighing the Benefits and Risks

This research reminds us that even seemingly safe medications, like a camel's ability to navigate the desert, can have potential side effects when used for prolonged periods. The study highlights the importance of carefully considering the risks and benefits of long-term treatment with isotretinoin, particularly in patients with certain risk factors.

Making Informed Decisions About Skin Care

This study, much like a camel finding a watering hole, highlights the need for careful monitoring and management of potential side effects of medications, even when used to treat serious conditions. It underscores the importance of open communication between patients and their [dermatologists], allowing for informed decision-making about treatment options.

Dr. Camel's Conclusion

This study, like a desert oasis, provides valuable information about the long-term effects of isotretinoin. While it can be a powerful tool for treating [skin conditions], it's essential to weigh the risks and benefits carefully. The study underscores the importance of personalized medicine, taking into account individual patient factors, and the need for close monitoring during long-term treatment.
Date :
  1. Date Completed 1993-09-16
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

8348061

DOI: Digital Object Identifier

8348061

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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