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Withdrawal from methadone maintenance. Rate of withdrawal and expectation.

Author: DorusW, GoldbergF, SenayE C, ThorntonW

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

Methadone withdrawal in patients successfully maintained on methadone hydrochloride was more effective when conducted at a rate of 3% of the initial dose per week compared to 10%. This approach resulted in lower dropout rates, less illicit drug use, fewer symptoms, and fewer requests for study interruption.
Paper Details　
Original Abstract of the Article :
One hundred twenty-seven successfully methadone-hydrochloride-maintained patients were randomly assigned to one of the following four groups and studied for 30 weeks: (1) known maintenance-patients were maintained on methadone under open conditions; (2) blind maintenance-patients were maintained on ...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1001/archpsyc.1977.01770150119014

データ提供：米国国立医学図書館（NLM）

Methadone Maintenance: A Journey of Withdrawal

Methadone maintenance is a complex and challenging process, like navigating a vast and unforgiving desert. This research delves into the process of withdrawal from methadone maintenance, examining the effects of different withdrawal rates on patient outcomes. The study compared four groups of patients: those maintained on methadone under open conditions, those maintained under double-blind conditions, those undergoing rapid withdrawal, and those undergoing gradual withdrawal.

Finding a Path to Recovery: Withdrawal Rates

The study reveals the importance of gradual withdrawal from methadone maintenance. The researchers found that a withdrawal rate of approximately 3% of the initial dose per week resulted in lower dropout rates, reduced illicit drug use, and fewer symptoms of withdrawal. They concluded that gradual withdrawal, coupled with careful patient preparation, is key to successful recovery.

Understanding the Complexities of Addiction

This research underscores the complexity of addiction and the importance of individualized treatment approaches. It highlights the need for careful planning and management during the withdrawal process to optimize patient outcomes and support recovery. Remember, addiction is a treatable condition, and there are resources available to help individuals navigate the challenges of recovery.

Dr.Camel's Conclusion

This research offers valuable insights into the process of methadone withdrawal, demonstrating the importance of gradual reduction and proper patient preparation. It's a reminder that recovery from addiction is a journey that requires careful guidance, support, and individualized care.

Date :
  1. Date Completed 1977-04-28
  2. Date Revised 2019-07-17
Further Info :

Pubmed ID

843188

DOI: Digital Object Identifier

10.1001/archpsyc.1977.01770150119014

Related Literature

Article Analysis
・Effects of methadone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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