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Clinical and immunological response to typhoid vaccination with parenteral or oral vaccines in two groups of 30 recruits.

Author: BiselliR, D'AmelioR, FattorossiA, MatricardiP M, NisiniR

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Oral typhoid vaccine was well-tolerated and induced a more robust immune response than parenteral vaccine.
Paper Details　
Original Abstract of the Article :
The clinical and immunological responses to typhoid vaccination with parenteral and oral vaccines in two groups of 30 adult male subjects were studied. Specific anti-Salmonella typhi cell-mediated immunity and total or specific anti-lipopolysaccharide faecal immunoglobulin (Ig) A titres in vaccinate...See full text at original site
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引用元：
https://doi.org/10.1016/0264-410x(93)90237-r

データ提供：米国国立医学図書館（NLM）

Typhoid Vaccination: Comparing Parenteral and Oral Vaccines

The search for effective vaccines to protect against infectious diseases is a constant quest, like exploring a vast desert for a life-giving oasis. This study compared the clinical and immunological responses to two different typhoid vaccines: a parenteral (injection) vaccine and an oral vaccine. The researchers aimed to assess the effectiveness and safety of each vaccine in inducing immune responses against Salmonella typhi, the bacterium responsible for typhoid fever.

A Different Approach: The Oral Vaccine

The study found that the oral vaccine was more effective in inducing cellular antibacterial activity and specific anti-lipopolysaccharide fecal IgA, suggesting a stronger immune response. Furthermore, the oral vaccine was well-tolerated, with no reported side effects, while the parenteral vaccine led to side effects in a significant proportion of the participants. The findings suggest that the oral vaccine may offer a more effective and safer alternative to the parenteral vaccine.

Choosing the Right Path to Typhoid Protection

This research provides valuable insights into the effectiveness and safety of typhoid vaccines. The findings suggest that the oral vaccine may be a more effective and safer option, particularly in terms of inducing a stronger immune response. However, it is crucial to consult with a healthcare professional to determine the most appropriate vaccine for your individual needs and to discuss any potential risks or side effects.

Dr.Camel's Conclusion

This study demonstrates that the path to typhoid protection can be paved with different approaches, each with its unique benefits and drawbacks. The oral vaccine appears to offer a more effective and safer option, but individual needs and preferences should be considered. Consult with a healthcare professional to determine the best route for achieving typhoid immunity.

Date :
  1. Date Completed 1993-06-09
  2. Date Revised 2019-07-28
Further Info :

Pubmed ID

8488716

DOI: Digital Object Identifier

10.1016/0264-410x(93)90237-r

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Languages

English

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