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Randomized trial of high-dose chemotherapy with autologous bone marrow support as adjuvant therapy for high-risk, multi-node-positive malignant melanoma.

Author: ConiglioD M, JonesR, MeisenbergB R, PetersW P, RossM, SeiglerH F, ShpallE J, VredenburghJ J, WuK

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Dacarbazine, a chemotherapy drug, has been shown to be effective in treating metastatic melanoma, with response rates of 15%-25%. Combining dacarbazine with other alkylating agents can improve response rates. High-dose chemotherapy regimens combined with autologous bone marrow support (transplantation) have yielded the highest response rates in treating metastatic melanoma.
Paper Details　
Original Abstract of the Article :
Chemotherapy adjuvant to surgery in metastatic melanoma has been evaluated in only a few prospective randomized trials. In the treatment of metastatic melanoma, dacarbazine has response rates of 15%-25% and in several studies, when combined with other alkylating agents, has yielded even higher respo...See full text at original site
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引用元：
https://doi.org/10.1093/jnci/85.13.1080

データ提供：米国国立医学図書館（NLM）

High-Dose Chemotherapy for Melanoma: A Promising Adjuvant Therapy

Malignant melanoma is a serious type of skin cancer that can be difficult to treat. This study investigated the potential of high-dose chemotherapy with autologous bone marrow support as an adjuvant therapy for high-risk, multi-node-positive malignant melanoma. The researchers conducted a randomized trial comparing high-dose chemotherapy with supportive care to surgery alone. The results showed that high-dose chemotherapy significantly improved disease-free survival in patients with high-risk melanoma.

High-Dose Chemotherapy: A Powerful Tool for Melanoma Treatment

This study provides evidence for the efficacy of high-dose chemotherapy as an adjuvant therapy for high-risk melanoma. This aggressive approach may offer a significant benefit in preventing disease recurrence and improving long-term survival for patients with this challenging cancer.

Navigating the Desert of Cancer Treatment: Choosing the Right Path

Treating melanoma requires a multifaceted approach. This study highlights the potential of high-dose chemotherapy, but it's important to weigh the potential benefits against the risks associated with this aggressive therapy. Consulting with an oncologist is crucial to determine the most appropriate treatment strategy for each individual patient.

Dr.Camel's Conclusion

This study is a ray of hope in the desert of melanoma treatment. High-dose chemotherapy, combined with bone marrow support, offers a promising avenue for improving outcomes for patients with high-risk melanoma. While this treatment is not without its challenges, it provides a valuable tool for fighting this serious disease.

Date :
  1. Date Completed 1993-07-21
  2. Date Revised 2019-05-12
Further Info :

Pubmed ID

8515495

DOI: Digital Object Identifier

10.1093/jnci/85.13.1080

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Article Analysis
・Effective treatment of melanoma
SNS
PICO Info
in preparation
Languages

English

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