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Dominant lethal and heritable translocation tests with chlorambucil and melphalan in male mice.

Author: CacheiroN L, CainK T, GenerosoW M, HughesL, LockhartA M, ShelbyM D, WittK L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

The study investigated the genetic and reproductive hazards associated with exposure to the chemotherapy drugs chlorambucil and melphalan. Both drugs were found to induce dominant lethal mutations and heritable translocations in male mice, particularly in postmeiotic germ cells.
Paper Details　
Original Abstract of the Article :
Chemicals used in the treatment of cancer include several that are potent mutagens in a range of in vitro and in vivo assays. For some, genetic effects have also been demonstrated in humans, detected as chromosomal aberrations in peripheral lymphocytes. Because (1) many of these agents are confirmed...See full text at original site
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引用元：
https://doi.org/10.1016/0165-1218(95)90052-7

データ提供：米国国立医学図書館（NLM）

Investigating the Genetic and Reproductive Hazards of Cancer Chemotherapy Agents

The use of [cancer chemotherapy agents] is a critical aspect of [cancer treatment], but these agents can also have [genetic and reproductive effects]. This research investigates the [mutagenic potential] of [chlorambucil and melphalan] in [male mice]. The researchers used [dominant lethal and heritable translocation tests] to assess the effects of these agents on [germ cells]. The results show that both [chlorambucil and melphalan] induced [dominant lethal mutations and heritable translocations] in [postmeiotic germ cells].

Understanding the Genetic Risks of Chemotherapy

The study's findings highlight the importance of considering the [genetic and reproductive risks] associated with [cancer chemotherapy]. The researchers' demonstration that [chlorambucil and melphalan] can induce [heritable translocations] in [germ cells] emphasizes the need for [careful monitoring] and [informed decision-making] when using these agents in [cancer treatment].

The Importance of Genetic Counseling in Cancer Care

This research underscores the importance of [genetic counseling] in [cancer care]. The study's findings suggest that [patients undergoing chemotherapy] may benefit from [counseling about the potential genetic and reproductive risks] associated with these treatments. This information can help patients make [informed decisions] about their treatment options and plan for future reproductive health.

Dr.Camel's Conclusion

Just like a camel's journey through the desert is fraught with challenges, the path of cancer treatment is often complex and full of unknowns. This study sheds light on the genetic risks associated with chemotherapy, emphasizing the importance of careful consideration and informed decision-making in cancer care.

Date :
  1. Date Completed 1996-02-22
  2. Date Revised 2019-07-02
Further Info :

Pubmed ID

8552138

DOI: Digital Object Identifier

10.1016/0165-1218(95)90052-7

Related Literature

Article Analysis
・Effective treatment of reproductive hazards
SNS
PICO Info
in preparation
Languages

English

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