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Diclofenac/misoprostol. A review of its pharmacology and therapeutic efficacy in painful inflammatory conditions.

Author: DavisR, GoaK L, YarkerY E

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), is associated with gastrointestinal side effects. Misoprostol, a prostaglandin E1 analogue, can reduce NSAID-related ulcers. While routine use of misoprostol for all NSAID users is not cost-effective, it may be beneficial for elderly patients. Diclofenac/misoprostol fixed combination therapy has shown similar efficacy to other NSAIDs with fewer ulcers and a similar incidence of adverse events in elderly and younger patients.
Paper Details　
Original Abstract of the Article :
Diclofenac is a well established nonsteroidal anti-inflammatory drug (NSAID) used in the treatment of a variety of painful inflammatory conditions. Although generally well tolerated, diclofenac, like other NSAIDs, is associated with gastrointestinal adverse effects which infrequently can be serious ...See full text at original site
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引用元：
https://doi.org/10.2165/00002512-199507050-00005

データ提供：米国国立医学図書館（NLM）

Diclofenac/Misoprostol: A Solution for Pain and Ulcer Prevention

The field of pain management is constantly striving to find effective and safe treatments for patients with painful inflammatory conditions. This review examines the pharmacology and therapeutic efficacy of the fixed combination of diclofenac, a non-steroidal anti-inflammatory drug (NSAID), and misoprostol, a prostaglandin E1 analogue, for managing these conditions. The authors highlight the potential of this combination to provide pain relief while reducing the risk of NSAID-induced gastrointestinal ulcers.

Diclofenac/Misoprostol: A Balancing Act

This review showcases the potential benefits of the diclofenac/misoprostol combination for managing painful inflammatory conditions. The authors note that this combination provides comparable pain relief to other NSAIDs, while significantly reducing the risk of gastrointestinal ulcers. This makes it a valuable option for patients who require NSAID therapy but are at increased risk for ulcer complications.

A Balancing Act: Pain Relief and Ulcer Prevention

This research highlights the importance of finding a balance between pain relief and minimizing adverse effects. The diclofenac/misoprostol combination offers a promising approach for managing painful inflammatory conditions, particularly for patients at risk for NSAID-induced ulcers. It's a reminder that effective pain management requires a careful assessment of individual patient needs and a commitment to maximizing benefit while minimizing risk.

Dr. Camel's Conclusion

This research is like finding a cool, refreshing spring in the middle of a scorching desert. It's a reminder that effective pain management requires a careful balance between relief and safety. The diclofenac/misoprostol combination offers a valuable tool for navigating this complex landscape.

Date :
  1. Date Completed 1996-03-12
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

8573992

DOI: Digital Object Identifier

10.2165/00002512-199507050-00005

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・Effects of diclofenac and misoprostol
SNS
PICO Info
in preparation
Languages

English

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