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Computerized planimetry in the objective assessment of the antispasmodic effect of Zamifenacin in double contrast barium enemas.

Author: HughesT, KeirM J, OwenJ P, WrightA R

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Zamifenacin, a gut-specific muscarinic receptor antagonist, was found to be safe and well tolerated but ineffective as an antispasmodic for double contrast barium enema examination at the prescribed dose.
Paper Details　
Original Abstract of the Article :
A prospective, randomized, double-blind study was undertaken to evaluate Zamifenacin 30 mg (Pfizer Ltd), a novel, orally-administered, gut-specific muscarinic receptor antagonist, as an adjuvant to the double contrast barium enema examination (DCBE). Zamifenacin was compared with placebo in terms of...See full text at original site
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引用元：
https://doi.org/10.1259/0007-1285-69-820-301

データ提供：米国国立医学図書館（NLM）

Zamifenacin for Double Contrast Barium Enemas: A Quest for Effective Antispasmodics

This study investigates the effectiveness of Zamifenacin, a novel muscarinic receptor antagonist, as an adjuvant to double contrast barium enemas (DCBE). Researchers conducted a randomized, double-blind study comparing Zamifenacin to placebo in terms of side effects and colonic tone. The study concluded that Zamifenacin, at the prescribed dose, was ineffective as an antispasmodic for DCBE. They also highlighted the importance of objective assessments, such as computerized planimetry, for reliable analysis of colonic tone.

Navigating the Desert of Colonic Tone: A Quest for Precision

This study emphasizes the importance of precise and objective assessments in medical research. It's like using a precise map to navigate a vast desert, ensuring that every step is measured and understood. The researchers found that subjective assessments were insufficient, highlighting the need for objective methods like computerized planimetry for accurate analysis.

The Quest for Effective Antispasmodics: A Journey Through the Gut

This study reinforces the ongoing search for effective antispasmodics for various medical procedures. It's like exploring the vast desert of the gut, seeking a solution to the challenges associated with colonic tone. The researchers found that Zamifenacin, while safe and well-tolerated, was ineffective in this specific context, highlighting the need for further research to identify more effective options.

Dr. Camel's Conclusion

This study emphasizes the importance of objective assessments in medical research and underscores the ongoing search for effective antispasmodics. The quest for effective antispasmodics continues, just like the relentless journey of a camel caravan through the desert. We must continue to explore new possibilities and refine our methods, ensuring that we reach our destination with the most effective tools at our disposal.

Date :
  1. Date Completed 1996-08-08
  2. Date Revised 2016-11-23
Further Info :

Pubmed ID

8665128

DOI: Digital Object Identifier

10.1259/0007-1285-69-820-301

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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