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Comparison of the effects of astemizole/pseudoephedrine and triprolidine/pseudoephedrine on CNS activity and psychomotor function.

Author: AlfordC A, HindmarchI, RombautN E, StanleyN

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This double-blind, placebo-controlled study compared the sedative properties of astemizole-D and triprolidine-D. Triprolidine-D was found to produce significantly more daytime sedation and drowsiness than astemizole-D or placebo. Astemizole-D did not produce daytime sedation or drowsiness, suggesting it may be a better option for patients who need to remain alert during the day.
Paper Details　
Original Abstract of the Article :
The sedative properties of astemizole-D and triprolidine-D were compared in a double-blind, placebo-controlled, repeated-measures design study comprising three experimental treatments, each with a duration of 2 days (n = 12). Sedation was assessed by continuous electroencephalographic measurement (C...See full text at original site
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引用元：
https://doi.org/10.1097/00004850-199603000-00004

データ提供：米国国立医学図書館（NLM）

Comparing the Effects of Astemizole/Pseudoephedrine and Triprolidine/Pseudoephedrine on CNS Activity and Psychomotor Function

This study investigated the sedative effects of two commonly used antihistamine-decongestant combinations, astemizole/pseudoephedrine and triprolidine/pseudoephedrine, on central nervous system (CNS) activity and psychomotor function. The study utilized a double-blind, placebo-controlled, repeated-measures design, involving three experimental treatments, each lasting two days. Sedation was assessed using continuous electroencephalographic (C-EEG) monitoring, intermittent performance testing, and subjective measures. The results indicated that triprolidine/pseudoephedrine produced significantly more daytime sedation and drowsiness than either astemizole/pseudoephedrine or placebo. Intermittent performance testing did not reveal consistent psychomotor deficits, except that astemizole/pseudoephedrine improved tracking accuracy compared to baseline. The study concluded that astemizole/pseudoephedrine, in contrast to triprolidine/pseudoephedrine, did not produce daytime drowsiness or sedation.

Understanding the Impact of Antihistamines on CNS Activity

This research provides valuable insights into the differential effects of antihistamines on CNS activity. The study's findings highlight the importance of carefully considering the potential sedative effects of certain medications, particularly when engaging in activities that require alertness and cognitive function.

Making Informed Decisions About Medications

It's essential to consult with a healthcare professional to make informed decisions about medications. Understanding the potential effects of medications, including their impact on CNS activity, allows individuals to make choices that support their overall health and well-being. Just as a wise traveler prepares for a desert journey by considering the potential obstacles, individuals should carefully weigh the benefits and risks of medications before using them.

Dr.Camel's Conclusion

As a camel, I appreciate the importance of a clear head and sharp senses when navigating the desert. This study highlights the need to carefully consider the potential effects of medications, particularly those that can impact CNS activity. By making informed decisions about our medications, we can ensure that we maintain our mental acuity and physical well-being, like a camel navigating the vast desert with confidence.
Date :
  1. Date Completed 1996-10-10
  2. Date Revised 2019-10-24
Further Info :

Pubmed ID

8732311

DOI: Digital Object Identifier

10.1097/00004850-199603000-00004

Related Literature

Article Analysis
・Effects of pseudoephedrine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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