Paper Details

  1. Home
  2. Paper Details

Different behavioral effects of haloperidol, clozapine and thioridazine in a concurrent lever pressing and feeding procedure.

Author: ChampionM, CousinsM S, KovachJ, MaioC, SalamoneJ D, TurskiT

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

This study found that haloperidol and clozapine suppress lever pressing for food through different mechanisms. Haloperidol suppressed lever pressing at low doses without producing severe motivational or sedative effects. Clozapine, however, suppressed lever pressing through a sedative effect that also limited food intake.
Paper Details　
Original Abstract of the Article :
Rats were tested using a lever pressing/feeding procedure in which a preferred food (Bioserve pellets) was available by pressing a lever on a fixed ratio 5 schedule, but a less preferred food (lab chow) was also available concurrently in the operant chamber. The effects of repeated (14 day) injectio...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1007/BF02249408

データ提供：米国国立医学図書館（NLM）

Haloperidol, Clozapine, and Thioridazine: Navigating the Desert of Behavior

The desert of behavior is vast and complex, with different pathways leading to varying outcomes. Antipsychotic medications, like travelers traversing the desert, can have diverse effects on behavior. This study, like a meticulous mapmaker, explores the distinct effects of haloperidol, clozapine, and thioridazine on rat behavior, seeking to understand the intricate mechanisms of these drugs.

Distinct Effects on Behavior: A Desert of Nuances

The researchers, like intrepid explorers venturing into the unknown, observed the effects of these antipsychotics on rat behavior. They found that haloperidol, like a strong desert wind, significantly reduced lever pressing for preferred food. Clozapine, on the other hand, suppressed lever pressing but had less impact on food intake, suggesting a different mechanism of action. Thioridazine, like a hybrid camel, showed effects resembling both haloperidol and clozapine.

Understanding the Landscape of Antipsychotic Effects

This study highlights the importance of understanding the nuances of antipsychotic medications. It's like navigating a desert where different paths can lead to vastly different destinations. Further research is needed to fully understand the mechanisms of these drugs and their impact on various aspects of behavior.

Dr.Camel's Conclusion

This research provides a valuable map of the diverse effects of antipsychotic medications on behavior. It reminds us that even in the desert of mental health, there are complex landscapes to explore, and careful navigation is crucial to ensure a successful journey.

Date :
  1. Date Completed 1997-04-03
  2. Date Revised 2019-07-26
Further Info :

Pubmed ID

8783383

DOI: Digital Object Identifier

10.1007/BF02249408

Related Literature

Article Analysis
・Effects of thioridazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.