Atovaquone as long-term suppressive therapy for toxoplasmic encephalitis in patients with AIDS and multiple drug intolerance. Atovaquone Expanded Access Group.

Author: GourdonD, KatlamaC, LapierreD, MouthonB, RousseauF

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To evaluate the efficacy and tolerance of atovaquone used as long-term maintenance therapy in patients with toxoplasmic encephalitis and intolerant of conventional anti-Toxoplasma therapies. DESIGN: Uncontrolled open-label study of atovaquone given through an expanded access programme; s...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/8874627

データ提供:米国国立医学図書館(NLM)

Atovaquone: A Potential Long-Term Treatment for Toxoplasmic Encephalitis

Toxoplasmic encephalitis, an infection of the brain caused by the parasite Toxoplasma gondii, is a serious health concern, particularly for individuals with weakened immune systems. This study explored the effectiveness of atovaquone as a long-term suppressive therapy for toxoplasmic encephalitis in patients with AIDS who were intolerant to conventional treatments. The study involved 65 patients who had experienced intolerance to traditional medications, and found that atovaquone was well-tolerated and effective in preventing relapses of toxoplasmic encephalitis. The study also discovered that a longer duration of pyrimethamine-sulphadiazine therapy during the acute phase of the infection was associated with a decreased risk of relapse during maintenance therapy.

Atovaquone: A Promising Alternative for Treatment-Intolerant Patients

The results of this study suggest that atovaquone can be a valuable alternative treatment option for patients with toxoplasmic encephalitis who are unable to tolerate conventional medications. The study found that atovaquone was effective in preventing relapses in 74% of patients. This is a significant finding, as it offers hope for patients who have previously struggled with intolerance to traditional treatments. This study's findings could potentially improve the lives of many patients with toxoplasmic encephalitis, providing them with a safe and effective treatment option.

Understanding Toxoplasmosis and its Impact on Health

Toxoplasmosis is a parasitic infection that can have serious consequences, especially for those with weakened immune systems. This study highlights the need for continued research into alternative treatment options for this infection. It also emphasizes the importance of early diagnosis and treatment to prevent complications.

Dr.Camel's Conclusion

This research is like finding a cool oasis in the middle of a scorching desert for individuals battling toxoplasmic encephalitis. The study's findings provide valuable insights into the potential of atovaquone as a long-term treatment option, offering hope and a path forward for patients who have faced challenges with traditional medications.

Date :
  1. Date Completed 1997-01-16
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

8874627

DOI: Digital Object Identifier

8874627

Related Literature

SNS
PICO Info
in preparation
Languages

English

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