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Rediscovering thalidomide: a review of its mechanism of action, side effects, and potential uses.

Author: PakG, PomeranzM K, ShupackJ L, TsengS, WashenikK

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Thalidomide has been found effective in treating various dermatologic diseases, including erythema nodosum leprosum, prurigo nodularis, and discoid lupus erythematosus. However, teratogenicity and peripheral neuropathy remain its limiting factors.
Paper Details　
Original Abstract of the Article :
Thalidomide, a hypnosedative drug introduced in the 1950s, has been used in a variety of dermatologic conditions during the past few decades. Although originally withdrawn from the world market on discovery of its teratogenic effect, it has since been selectively reintroduced for use in various diso...See full text at original site
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引用元：
https://doi.org/10.1016/s0190-9622(96)90122-x

データ提供：米国国立医学図書館（NLM）

Thalidomide: A Phoenix Rising from the Desert

Thalidomide, a drug once withdrawn from the market due to its teratogenic effects, has resurfaced as a potential treatment for various dermatological conditions. This study reviews the current understanding of thalidomide's mechanism of action, side effects, and potential uses in dermatology.

The study highlights thalidomide's effectiveness in treating a range of dermatological conditions, including erythema nodosum leprosum, prurigo nodularis, actinic prurigo, discoid lupus erythematosus, aphthous stomatitis, Behçet's syndrome, and graft-versus-host disease. However, the authors emphasize the importance of vigilance for potential side effects, such as teratogenicity and peripheral neuropathy.

A Camel's Oasis of Treatment

The study's findings suggest that thalidomide, despite its history, can be a valuable tool for managing certain dermatological conditions. However, the potential for serious side effects requires careful consideration and monitoring.

A Camel's Compass for Dermatology

This research underscores the importance of understanding the complex interplay between drugs, their mechanisms of action, and potential side effects. While thalidomide offers a promising option for some dermatological conditions, careful evaluation and management are crucial.

Dr. Camel's Conclusion

This study explores the complex history of thalidomide, a drug that has risen from the ashes of controversy to offer potential benefits in dermatology. While its past necessitates caution, thalidomide may provide a valuable therapeutic option for patients with certain dermatological conditions.

Date :
  1. Date Completed 1997-01-09
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

8959957

DOI: Digital Object Identifier

10.1016/s0190-9622(96)90122-x

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PICO Info
in preparation
Languages

English

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