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Blood pressure and blood glucose levels during a cross-over treatment of doxazosin, moduretic and amlodipine in hypertensive patients.

Author: AhanekuJ E

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Doxazosin was effective in reducing blood pressure and lowering blood glucose levels in hypertensive Nigerian patients, while amlodipine controlled blood pressure but did not affect blood glucose, and moduretic controlled blood pressure but increased blood glucose levels.
Paper Details　
Original Abstract of the Article :
A cross-over study comparing the effects of doxazosin, moduretic and amlodipine on fasting blood glucose and blood pressure levels in 9 adult hypertensive Nigerians is presented. The results showed that doxazosin, moduretic and amlodipine were effective in reducing diastolic blood pressure and thus ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/8984227

データ提供：米国国立医学図書館（NLM）

A Balancing Act: Comparing Antihypertensive Medications on Blood Pressure and Blood Glucose

In the bustling marketplace of antihypertensive medications, researchers set out to understand the effects of doxazosin, moduretic, and amlodipine on both blood pressure and blood glucose levels. This cross-over study, conducted on 9 adult hypertensive Nigerians, provides valuable insights into the unique characteristics of these medications. The study found that all three medications were effective in reducing diastolic blood pressure. However, doxazosin demonstrated an additional benefit in lowering fasting blood glucose levels, while moduretic had the opposite effect, leading to an increase in blood glucose. Amlodipine, on the other hand, didn't show any significant effect on blood glucose.

Doxazosin: A Potential Double-Edged Sword

The study suggests that doxazosin might be a beneficial choice for hypertensive patients with concerns about blood glucose control. However, it's crucial to consider the potential hyperglycemic effect of moduretic and the neutral effect of amlodipine. Further research is needed to clarify the long-term implications of these effects and to determine the optimal treatment strategy for individual patients.

Navigating Blood Pressure and Blood Sugar: A Balanced Approach

Balancing blood pressure and blood glucose levels is vital for overall health. If you're managing hypertension, it's essential to discuss treatment options with your doctor, considering your individual health profile and potential risks. They can guide you towards a medication that effectively manages your blood pressure without negatively impacting your blood glucose.

Dr.Camel's Conclusion

In the vast desert of antihypertensive medications, doxazosin, moduretic, and amlodipine each offer their own unique properties. Doxazosin stands out as a potential double-edged sword, effectively managing blood pressure while demonstrating a beneficial effect on blood glucose. However, the hyperglycemic effect of moduretic and the neutral effect of amlodipine warrant careful consideration. Remember, navigating the complexities of blood pressure and blood sugar management requires a personalized approach guided by your doctor.
Date :
  1. Date Completed 1997-01-07
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

8984227

DOI: Digital Object Identifier

8984227

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