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Plasma-diazepam in infants after rectal administration in solution and by suppository.

Author: KnudsenF U

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Diazepam was given rectally as a solution (0.7 mg/kg) or a suppository (5 mg) to 20 infants with febrile convulsions. Diazepam in solution reached anticonvulsant plasma levels within 4 +/- 1 min, while suppository administration resulted in similar levels after 20-30 min. Rectal diazepam solution may be useful in the acute treatment of febrile convulsions, while the suppository form is less effective. The study suggests that rectal diazepam solution may be suitable for home use in case of recurrent febrile convulsions, but further research is needed to evaluate its anticonvulsant effects and side effects.
Paper Details　
Original Abstract of the Article :
Twenty infants aged 1-2 years who had previously had one attack of febrile convulsions were randomly given a single dose of diazepam rectally, either as a solution (0.7 mg/kg) or by suppository (5 mg). Plasma-diazepam levels were determined repeatedly during the first hour using gas chromatography. ...See full text at original site
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引用元：
https://doi.org/10.1111/j.1651-2227.1977.tb07947.x

データ提供：米国国立医学図書館（NLM）

Diazepam Delivery: A Race Against Time

Febrile convulsions, a common occurrence in infants, are a medical emergency. Diazepam, an anticonvulsant medication, is often used to manage these seizures. This research explores the effectiveness of two different methods of administering diazepam rectally: as a solution and as a suppository.

The study found that administering diazepam as a solution resulted in faster absorption and therapeutic plasma levels compared to the suppository form. The researchers suggest that rectal diazepam solution may be a more effective and efficient option for the acute treatment of febrile convulsions.

A Quick Solution for a Time-Sensitive Situation

This research highlights the importance of rapid delivery of diazepam in managing febrile convulsions. The study's findings suggest that the solution form offers a faster and more effective way to achieve therapeutic plasma levels. This could be crucial for minimizing the duration and severity of seizures in infants.

Dr.Camel's Conclusion

When it comes to febrile convulsions in infants, time is of the essence. This study shows that diazepam solution given rectally is a swift and effective camel in the desert of treatment options, potentially leading to faster seizure control and improved outcomes.

Date :
  1. Date Completed 1977-10-28
  2. Date Revised 2019-08-19
Further Info :

Pubmed ID

899774

DOI: Digital Object Identifier

10.1111/j.1651-2227.1977.tb07947.x

SNS
PICO Info
in preparation
Languages

English

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