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Triazolam is ineffective in patients taking rifampin.

Author: BackmanJ T, KivistöK T, NeuvonenP J, OlkkolaK T, VillikkaK

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Rifampin significantly reduced plasma concentrations and effects of triazolam, indicating a potential drug interaction.
Paper Details　
Original Abstract of the Article :
Triazolam is metabolized predominantly by cytochrome P450 3A4 (CYP3A4). Rifampin (rifampicin) is a potent inducer of CYP3A4 and it is known to markedly reduce plasma concentrations and effects of drugs such as midazolam. The possible interaction between rifampin and triazolam was examined in this st...See full text at original site
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引用元：
https://doi.org/10.1016/S0009-9236(97)90176-4

データ提供：米国国立医学図書館（NLM）

Triazolam Ineffectiveness: A Case of Drug Interactions in the Desert of Pharmacology

Triazolam is a benzodiazepine medication often used for insomnia. However, like a camel that can't navigate the shifting sands of drug interactions, its effectiveness can be significantly compromised in the presence of certain medications. This study explores the interaction between triazolam and rifampin.

Rifampin: A Sandstorm in the Desert of Metabolism

Rifampin is a potent inducer of cytochrome P450 3A4 (CYP3A4), an enzyme involved in drug metabolism. This induction can significantly reduce the plasma concentrations and effects of drugs metabolized by CYP3A4, including triazolam. It's like a sandstorm that disrupts the delicate balance of a camel's digestive system, hindering its ability to absorb and utilize nutrients.

Navigating Drug Interactions: A Careful Approach

This study emphasizes the importance of understanding drug interactions and consulting with healthcare professionals to avoid potential complications. It's like having a knowledgeable guide who can identify and navigate the treacherous dunes of drug interactions, ensuring a safe and effective medication journey.

Dr.Camel's Conclusion

This research highlights the importance of considering drug interactions when prescribing medications. It serves as a reminder that the desert of pharmacology is filled with complex pathways and potential pitfalls that must be carefully navigated. It's like being a skilled camel trainer who understands the nuances of each animal's metabolism and can adjust their care accordingly.
Date :
  1. Date Completed 1997-02-27
  2. Date Revised 2018-12-11
Further Info :

Pubmed ID

9024169

DOI: Digital Object Identifier

10.1016/S0009-9236(97)90176-4

Related Literature

Article Analysis
・Effects of rifampin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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