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Centrally acting antihypertensives: a renaissance of interest. Mechanisms and haemodynamics.

Author: van ZwietenP A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Classic centrally acting antihypertensives stimulate alpha2-adrenoceptors in the pontomedullary region, leading to peripheral sympathoinhibition and a reduction in blood pressure through vasodilation.
Paper Details　
Original Abstract of the Article :
Classic centrally acting antihypertensives are known to stimulate alpha2-adrenoceptors located in the pontomedullary region, in the vicinity of the nucleus tractus solitarii, vasomotor centre, vagal nucleus and the various interconnecting neurones. The stimulation of these central alpha2-adrenocepto...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/9050980

データ提供：米国国立医学図書館（NLM）

Centrally Acting Antihypertensives: A Renaissance of Interest

This review examines the mechanisms and hemodynamics of centrally acting antihypertensives, highlighting their resurgence in interest. The authors explain that these drugs act by stimulating alpha2-adrenoceptors located in the pontomedullary region of the brainstem. This stimulation leads to peripheral sympathoinhibition, resulting in reduced blood pressure primarily through vasodilation and a decrease in peripheral vascular resistance.

Centrally Acting Antihypertensives: A Novel Approach to Blood Pressure Control

The review suggests that centrally acting antihypertensives offer a unique approach to blood pressure management. By targeting the central nervous system, these drugs can effectively reduce sympathetic activity and lower blood pressure without the need for peripheral vasoconstriction.

Managing Hypertension: Exploring Treatment Options

If you are diagnosed with hypertension, it's crucial to consult with your healthcare provider to discuss treatment options. This review highlights the potential benefits of centrally acting antihypertensives as a therapeutic strategy for managing blood pressure. Your healthcare provider can assess your individual needs and recommend the most appropriate treatment plan.

Dr.Camel's Conclusion

This review, like a camel navigating the vast desert of cardiovascular research, examines the mechanisms and therapeutic potential of centrally acting antihypertensives. The review sheds light on a promising approach to blood pressure management, highlighting the potential benefits of targeting the central nervous system to reduce sympathetic activity and lower blood pressure.

Date :
  1. Date Completed 1997-05-15
  2. Date Revised 2013-07-15
Further Info :

Pubmed ID

9050980

DOI: Digital Object Identifier

9050980

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Languages

English

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