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[Studies on the in vitro bactericidal effects of cephalexin against Staphylococcus aureus (author's transl)].

Author: KatoH, KitagakiY, KuwabaraY, NakamuraM, NishimuraK

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Cephalexin was studied for its effect on the number of viable cells in two strains of Staph. aureus and six strains of Escherichia coli. The study found that exposure time was more important than concentration in decreasing the number of cells. A 4-hour exposure to 1 MIC of cephalexin was more effective than a 2-hour twice exposure at a 4-hour nonexposure interval to 4 MICs of cephalexin in decreasing the number of viable cells for 12 hours.
Paper Details　
Original Abstract of the Article :
The effect of cephalexin on the numbers of viable cells was studied. Two strains of Staph. aureus and 6 strains of Escherichia coli at their logarithmic phase were exposed to various concentrations (1 approximately 4 MICs) of cephalexin for 1 approximately 24 hours in vitro. The numbers of viable ce...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/909150

データ提供：米国国立医学図書館（NLM）

The Bactericidal Effects of Cephalexin: A Closer Look

Antibiotics are essential tools in fighting bacterial infections, but understanding how they work at the cellular level is crucial for optimal treatment. This research explores the in vitro bactericidal effects of cephalexin against Staphylococcus aureus and Escherichia coli. The study investigated how exposure time and concentration of cephalexin impact bacterial viability.

Time is Key: Longer Exposure, Greater Effect

The study found that longer exposure times were more effective in reducing viable bacteria cells than higher concentrations of cephalexin. This finding suggests that sustained exposure to the antibiotic is key to effectively killing bacteria.

Understanding Bacterial Sensitivity: A Guide to Treatment

The study emphasizes the importance of understanding how different bacteria respond to antibiotics. This knowledge can help clinicians choose the appropriate antibiotic and dosage for a particular infection.

Dr. Camel's Conclusion

Imagine a camel caravan facing a sandstorm. Just like a sandstorm requires a steady approach, bacteria require sustained exposure to antibiotics for effective eradication. This study sheds light on the importance of proper antibiotic administration and the need for a deeper understanding of bacterial sensitivity.

Date :
  1. Date Completed 1977-11-30
  2. Date Revised 2016-11-16
Further Info :

Pubmed ID

909150

DOI: Digital Object Identifier

909150

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Languages

Japanese

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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