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The safety and efficacy of oral methylnaltrexone in preventing morphine-induced delay in oral-cecal transit time.

Author: FossJ F, MossJ, OsinskiJ, RoizenM F, ToledanoA, YuanC S

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Oral methylnaltrexone, a quaternary opioid antagonist, effectively prevented morphine-induced delay in gastrointestinal transit in healthy volunteers. This suggests its potential use in managing opioid-induced constipation.
Paper Details　
Original Abstract of the Article :
Methylnaltrexone is a quaternary opioid antagonist with limited ability to cross the blood-brain barrier that has the potential to antagonize the peripherally mediated gastrointestinal effects of opioids. In recent trials in human volunteers, we demonstrated that intravenous methylnaltrexone prevent...See full text at original site
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引用元：
https://doi.org/10.1016/S0009-9236(97)90197-1

データ提供：米国国立医学図書館（NLM）

Methylnaltrexone: A Potential Solution for Opioid-Induced Constipation

The use of [opioids] for pain management often comes with the side effect of [constipation]. This study investigates the efficacy and safety of [oral methylnaltrexone] in preventing [morphine-induced delay in oral-cecal transit time]. Researchers conducted a [double-blind, randomized study] involving [14 healthy volunteers] and found that [oral methylnaltrexone significantly attenuated the morphine-induced delay in oral-cecal transit time]. The study suggests that [oral methylnaltrexone] may have clinical value in the prevention and treatment of [constipation induced by long-term opioid use].

Methylnaltrexone: A Potential Solution for Opioid-Induced Constipation

This study offers a potential solution for a common challenge associated with [opioid therapy]. [Oral methylnaltrexone] has shown promise in reducing [constipation] without affecting analgesia, indicating a potential to improve patient comfort and adherence to opioid treatment. The findings warrant further investigation to confirm these results and explore the optimal dosage and long-term effects of this medication.

Methylnaltrexone: A Potential Solution for Opioid-Induced Constipation

Navigating the complex world of [opioid therapy] often involves finding ways to mitigate side effects, such as [constipation]. This research provides a glimmer of hope for a potential solution, suggesting that [oral methylnaltrexone] may offer a safe and effective way to manage this common issue. It's crucial to consult with your healthcare provider to determine if this medication is suitable for you and to discuss any potential risks or benefits.

Dr. Camel's Conclusion

This study, like a well-trodden path in the desert, points towards a potential solution for the challenges of [opioid-induced constipation]. While more research is needed, the promising results of [oral methylnaltrexone] provide a beacon of hope for improving patient comfort and well-being. As with any medical intervention, it's essential to consult with a healthcare professional to make informed decisions and explore the best path forward for your individual needs.

Date :
  1. Date Completed 1997-05-15
  2. Date Revised 2016-11-24
Further Info :

Pubmed ID

9129564

DOI: Digital Object Identifier

10.1016/S0009-9236(97)90197-1

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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