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Tazarotene gel, a new retinoid, for topical therapy of psoriasis: vehicle-controlled study of safety, efficacy, and duration of therapeutic effect.

Author: ChandraratnaR A, DuvicM, FriedmanD J, GibsonJ R, JegasothyB V, JorizzoJ L, KruegerG G, Lew-KayaD A, LoweN J, LueJ C, SeftonJ, ShmunesE, TschenE H, WeinsteinG D

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Once-daily tazarotene was effective and safe as a topical monotherapy for plaque psoriasis, providing rapid reduction of signs and symptoms. Tazarotene gels were superior to vehicle in all efficacy measures, including plaque elevation, scaling, and erythema.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Topical therapy providing initial improvement and maintenance of effect after treatment of the large majority of patients with limited, mild to moderate psoriasis is not presently available. Previous topical retinoids have generally been either ineffective or too irritating for therapy o...See full text at original site
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引用元：
https://doi.org/10.1016/s0190-9622(97)70216-0

データ提供：米国国立医学図書館（NLM）

A New Hope for Psoriasis: Tazarotene Gel Shines

In the vast desert of dermatological research, finding a treatment for psoriasis that provides both initial improvement and long-lasting relief for the majority of patients has been a challenging quest. Existing topical retinoids have often fallen short, either proving ineffective or causing excessive irritation. This study, published in the Journal of the American Academy of Dermatology, presents a new player in the game: tazarotene gel.

This research, led by a group of dedicated dermatologists, sought to evaluate the safety and efficacy of tazarotene gel, a novel topical retinoid, in treating stable plaque psoriasis. In a double-blind study, 324 patients were randomly assigned to receive tazarotene gel (at two concentrations) or a vehicle control. They were then followed for 12 weeks after treatment.

A Beacon of Hope in the Desert of Psoriasis

The results were as clear as a desert sky after a rare rainfall. Tazarotene gel proved superior to the vehicle control in all efficacy measures. It effectively reduced plaque elevation, scaling, and erythema, leading to a significant improvement in treatment response and overall success rate. The therapeutic effects persisted even after the treatment period ended.

A Oasis of Relief: What This Means for You

For patients suffering from psoriasis, this research offers a glimmer of hope. Tazarotene gel offers a safe and effective topical monotherapy option that could provide rapid relief from the bothersome symptoms of psoriasis. It's like finding a refreshing oasis in the midst of a challenging desert journey!

Dr.Camel's Conclusion

The findings of this study highlight the potential of tazarotene gel as a valuable treatment option for patients with plaque psoriasis. It has shown promise in improving both short-term and long-term outcomes, offering a ray of hope in the desert of this chronic condition.

Date :
  1. Date Completed 1997-08-04
  2. Date Revised 2021-04-09
Further Info :

Pubmed ID

9216528

DOI: Digital Object Identifier

10.1016/s0190-9622(97)70216-0

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Article Analysis
・Effective treatment of psoriasis
SNS
PICO Info
in preparation
Languages

English

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