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Reduction of dizocilpine and scopolamine-induced deficits in avoidance responding by SCH 54388, a metabolite of felbamate.

Author: CoffinV L, GrzelakM E, SmithR D

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study compared the effects of felbamate, a novel antiepileptic drug, and its metabolite SCH 54388 on scopolamine and dizocilpine-induced deficits in a mouse passive-avoidance paradigm. SCH 54388 was more effective than felbamate in reducing these deficits, suggesting that it may act on both glutaminergic and cholinergic central neuronal systems.
Paper Details　
Original Abstract of the Article :
Felbamate (2-phenyl-1,3-propanediol dicarbamate) is a novel antiepileptic agent with a unique structure and mechanism of action, possibly involving binding sites at the N-methyl-D-aspartate receptor (NMDA) complex. A monocarbomate metabolite of felbamate (SCH 54388) was compared to felbamate using a...See full text at original site
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引用元：
https://doi.org/10.1016/s0091-3057(97)00027-0

データ提供：米国国立医学図書館（NLM）

A New Direction for Epilepsy Treatment

Epilepsy is a condition that can disrupt lives, leaving those affected feeling like they're navigating a desert of unpredictable seizures. Finding effective treatments is essential for managing this condition. This study explores the potential of a new drug, SCH 54388, for treating epilepsy.

The researchers are investigating the mechanism of action of SCH 54388, a metabolite of the drug felbamate. They're examining its ability to reduce the effects of certain drugs that can induce seizures, suggesting a potential role in preventing or reducing seizures.

The study found that SCH 54388 was effective in reducing the effects of scopolamine and dizocilpine, both drugs known to induce seizures. This suggests that SCH 54388 may have potential for treating epilepsy.

A Promising Solution for a Difficult Condition

This study highlights the potential of SCH 54388 as a new treatment for epilepsy. Its ability to reduce the effects of seizure-inducing drugs suggests a promising avenue for managing this challenging condition.

Exploring the Possibilities

Further research is needed to fully understand the efficacy and safety of SCH 54388 for epilepsy. However, this study offers hope for new and effective treatment options for those struggling with this condition.

Dr. Camel's Conclusion

Finding effective treatments for epilepsy is like searching for water in the desert - a challenging but rewarding journey. This study offers a promising new direction for epilepsy treatment, and it reminds us of the importance of research and innovation in finding solutions for complex medical conditions.

Date :
  1. Date Completed 1998-02-06
  2. Date Revised 2019-07-12
Further Info :

Pubmed ID

9329055

DOI: Digital Object Identifier

10.1016/s0091-3057(97)00027-0

Related Literature

Article Analysis
・Side Effects of felbamate
SNS
PICO Info
in preparation
Languages

English

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