Paper Details

  1. Home
  2. Paper Details

Famciclovir treatment of hepatitis B virus recurrence after liver transplantation: a pilot study.

Author: BodeU, BroelschC E, BökerK H, KrügerM, MannsM P, MaschekH, OldhaferK, PichlmayrR, TillmannH L, TrautweinC

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Famciclovir is a well-tolerated antiviral drug that effectively reduces hepatitis B virus (HBV) replication in patients with HBV recurrence after liver transplantation. In a pilot study, 75% of patients saw a significant reduction in HBV DNA levels after 3 months, and 5 out of 9 patients became negative by conventional hybridization assay. While one patient died due to sepsis and peritonitis, no other clinically significant side effects were observed.
Paper Details　
Original Abstract of the Article :
Despite hepatitis B immunoprophylaxis hepatitis B virus (HBV) recurrence is a frequent and often fatal complication after orthotopic liver transplantation (OLT). The purine nucleoside analogues penciclovir and its oral form famciclovir (FCV) proved to be well tolerated and effective against herpes s...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1002/lt.500020402

データ提供：米国国立医学図書館（NLM）

Famciclovir Treatment for Hepatitis B Recurrence After Liver Transplantation

This study delves into the challenging terrain of [hepatitis B virus recurrence] after liver transplantation, a situation akin to a treacherous sandstorm. The researchers investigate the potential of [famciclovir] as a treatment option, much like searching for a hidden oasis amidst the storm. They found that [famciclovir] appears to be a promising tool for combating HBV recurrence, offering a beacon of hope in this daunting situation.

Famciclovir Shows Promise in Combating HBV Recurrence

The researchers' findings indicate that [famciclovir is effective in reducing HBV DNA levels and transaminase levels in patients with HBV recurrence], a discovery akin to finding a wellspring of fresh water in the desert. The results suggest that famciclovir could be a valuable weapon against this potentially fatal complication after liver transplantation.

Hope for Patients with HBV Recurrence

This research offers a potential lifeline for patients who face the daunting challenge of HBV recurrence after liver transplantation. The findings suggest that [famciclovir could potentially improve the lives of these patients] by offering a more effective treatment option. It's like finding a new and reliable source of water in a parched landscape.

Dr.Camel's Conclusion

The study offers a ray of hope for patients battling the challenges of HBV recurrence following liver transplantation. The researchers' findings suggest that famciclovir might be a valuable addition to the treatment arsenal, paving the way for more effective management and improved patient outcomes. This research is a beacon of light in the desert, illuminating the path towards better treatment and ultimately, improved survival.

Date :
  1. Date Completed 1997-12-04
  2. Date Revised 2021-12-03
Further Info :

Pubmed ID

9346658

DOI: Digital Object Identifier

10.1002/lt.500020402

Related Literature

Article Analysis
・Side Effects of famciclovir
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.