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Twice a day quadruple therapy (bismuth subsalicylate, tetracycline, metronidazole plus lansoprazole) for treatment of Helicobacter pylori infection.

Author: GrahamD P, GrahamD Y, HoffmanJ, OsatoM, el-ZimaityH M

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

Twice-a-day quadruple therapy was effective for metronidazole-sensitive strains of Helicobacter pylori, but less effective for metronidazole-resistant strains.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Quadruple therapy (bismuth, metronidazole and tetracycline (BMT) + proton pump inhibitor) is touted as being > 95% effective, regardless of metronidazole resistance. We tested a 10-day b.d. quadruple therapy for treatment of H. pylori infection. METHODS: Anti-H. pylori therapy consisted...See full text at original site
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引用元：
https://doi.org/10.1046/j.1365-2036.1997.00219.x

データ提供：米国国立医学図書館（NLM）

Evaluating the Efficacy of Twice-Daily Quadruple Therapy for Helicobacter pylori Infection

This study investigates the effectiveness of a twice-daily quadruple therapy regimen for treating Helicobacter pylori infection, a common cause of gastritis and peptic ulcers. The study compared the cure rates of patients receiving this regimen to those with metronidazole-resistant strains. The findings demonstrate a significant difference in cure rates, with a significantly higher success rate in patients with metronidazole-sensitive strains. While the regimen was effective for metronidazole-sensitive strains, its effectiveness was reduced for metronidazole-resistant strains, highlighting the importance of understanding antimicrobial resistance patterns.

Navigating Antibiotic Resistance: A Growing Challenge in Healthcare

This study underscores the critical challenge of antibiotic resistance in healthcare. The researchers' findings emphasize the need for appropriate diagnostic testing to identify resistance patterns and guide treatment decisions.

Personalized Treatment for Helicobacter pylori Infection: A Tailored Approach

This research highlights the importance of personalized treatment approaches for Helicobacter pylori infection. The study's findings suggest that the choice of therapy should be tailored to individual patients' resistance profiles, ensuring the most effective treatment possible.

Dr. Camel's Conclusion

This research provides valuable insights into the efficacy of a twice-daily quadruple therapy regimen for Helicobacter pylori infection. The study's findings underscore the importance of considering antimicrobial resistance patterns in treatment decisions. While the regimen was effective for metronidazole-sensitive strains, its effectiveness was reduced for metronidazole-resistant strains, highlighting the need for personalized approaches to treatment. The fight against antibiotic resistance is a crucial endeavor, and this research offers important lessons for optimizing treatment strategies for Helicobacter pylori infection.

Date :
  1. Date Completed 1997-12-18
  2. Date Revised 2019-08-31
Further Info :

Pubmed ID

9354203

DOI: Digital Object Identifier

10.1046/j.1365-2036.1997.00219.x

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PICO Info
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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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