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Effects of dietary pyrazinamide on the metabolism of tryptophan to niacin in streptozotocin-diabetic rats.

Author: IshikawaA, KondoT, ShibataK

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effects of feeding with a pyrazinamide (PYR) diet on the metabolism of L-tryptophan (Trp) to nicotinamide in streptozotocin (STZ)-diabetic rats. Feeding with the PYR diet increased nicotinamide formation, but did not improve blood glucose levels or prevent the diabetic action of STZ.
Paper Details　
Original Abstract of the Article :
We investigated the effects of feeding with a diet containing pyrazinamide (PYR) on the metabolism of L-tryptophan (Trp) to nicotinamide in streptozotocin (STZ)-diabetic rats and whether the diabetic action of STZ is prevented by feeding with the PYR diet, which is known as an inhibitor of aminocarb...See full text at original site
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引用元：
https://doi.org/10.1271/bbb.61.1679

データ提供：米国国立医学図書館（NLM）

Pyrazinamide and Tryptophan Metabolism: A Desert of Dietary Interactions

The field of [nutritional biochemistry] investigates the complex interactions between diet and metabolism. This study explores the effects of [dietary pyrazinamide] on the [metabolism of tryptophan to niacin] in [streptozotocin-diabetic rats]. The researchers found that feeding a diet containing pyrazinamide significantly increased the [formation of nicotinamide] from tryptophan in diabetic rats. While this increased nicotinamide production did not improve blood glucose levels, it did lead to an increase in body weight, suggesting a potential role for pyrazinamide in [nutritional interventions] for diabetic patients.

A Desert Oasis of Niacin: Exploring Pyrazinamide's Effects

The study's findings suggest that [pyrazinamide] may influence the [metabolism of tryptophan] to [niacin], a crucial nutrient for various bodily functions. This study provides evidence for the potential role of [dietary interventions] in managing diabetes.

Pyrazinamide and Diabetes: A Journey Through a Desert of Metabolism

Diabetes is a complex metabolic condition that requires careful management. This study explores the potential of dietary interventions to influence the metabolism of essential nutrients in diabetic patients. The study's findings suggest that pyrazinamide may play a role in regulating tryptophan metabolism and influencing overall health in diabetic individuals.

Dr. Camel's Conclusion

This study is a journey through the desert of nutritional biochemistry, exploring the effects of pyrazinamide on tryptophan metabolism. The researchers found that pyrazinamide can increase the formation of nicotinamide from tryptophan, potentially influencing overall health in diabetic patients. Like a camel seeking a source of water in a vast and arid landscape, we must continue to explore the complex interplay between diet and metabolism to find solutions to the challenges of chronic diseases.

Date :
  1. Date Completed 1999-05-18
  2. Date Revised 2019-09-09
Further Info :

Pubmed ID

9362115

DOI: Digital Object Identifier

10.1271/bbb.61.1679

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・Effects of pyrazinamide
SNS
PICO Info
in preparation
Languages

English

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