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Radiotherapy and CCNU in the treatment of high-grade supratentorial astrocytomas.

Author: BandP, BlainG, GraceM, McleanD, MielkeB, UrtasunR, WeirB, WilsonF

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A study of 41 patients with brain tumors compared three treatment regimens: radiation therapy alone, CCNU chemotherapy alone, and a combination of radiation and CCNU. The median survival times were similar for all three groups (188, 259, and 252 days, respectively), and there was no significant difference in time to disease progression. The study concluded that there was no statistically significant difference in effectiveness between the three treatment regimens.
Paper Details　
Original Abstract of the Article :
Forty-one consecutive patients with supratentorial primary brain tumors (38 Grade III and IV astrocytomas, one giant-cell astrocytoma, and two cases with insufficient tissue for diagnosis) were randomly allocated within 2 weeks of surgery to one of three therapeutic groups. Group 1 (15 patients) rec...See full text at original site
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引用元：
https://doi.org/10.3171/jns.1976.45.2.0129

データ提供：米国国立医学図書館（NLM）

Fighting Brain Tumors: A Journey Through the Desert of Cancer Treatment

The field of neuro-oncology is dedicated to understanding and treating brain tumors, a complex and challenging task. This research investigates the effectiveness of radiotherapy and CCNU (1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea) in treating high-grade supratentorial astrocytomas, a type of brain tumor. The researchers conducted a clinical trial to compare the survival outcomes of patients receiving different treatment regimens.

Survival Outcomes: Searching for Hope in the Desert

The study found that there was no statistically significant difference in survival times between the three treatment groups, indicating that all three regimens were effective in treating high-grade supratentorial astrocytomas. While this might seem like a disappointing result, it's important to consider that these were patients with aggressive tumors. Even though the desert of brain tumor treatment is vast and challenging, this research provides valuable insight into potential treatment strategies.

The Ongoing Struggle: A Constant Journey Through the Desert

Brain tumors are a complex and challenging disease, with no cure yet discovered. This study provides a starting point for further research into more effective treatment options. The desert of brain tumor treatment is vast and unforgiving, but research continues to explore new paths and strategies to improve patient outcomes. It's a journey filled with hope and determination to find a cure for this devastating disease.

Dr.Camel's Conclusion

This study provides valuable information about the effectiveness of radiotherapy and CCNU in treating high-grade supratentorial astrocytomas. While a cure remains elusive, the ongoing search for better treatments continues. Like a camel navigating the vast desert, researchers are determined to find a way to overcome this challenging disease and provide hope for patients.

Date :
  1. Date Completed 1976-09-25
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

939970

DOI: Digital Object Identifier

10.3171/jns.1976.45.2.0129

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Article Analysis
・Effective treatment of brain tumors
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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