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The aromatase inhibitor letrozole in advanced breast cancer: effects on serum insulin-like growth factor (IGF)-I and IGF-binding protein-3 levels.

Author: BajettaE, BichisaoE, BuzzoniR, CelioL, Di LeoA, FerrariL, MarianiL, MartinettiA, MiceliR, SeregniE, SpagnoliI, ZilemboN

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Letrozole increased serum IGF-I levels in postmenopausal women with advanced breast cancer, but further studies are needed to confirm this finding and understand its clinical significance.
Paper Details　
Original Abstract of the Article :
Serum insulin-like growth factor (IGF)-I and IGF-binding protein-3 levels were measured in two groups of postmenopausal women with advanced breast cancer, who received the aromatase inhibitor letrozole 0.5 or 2.5 mg p.o. once daily. Blood samples were obtained from 15 patients in each dose group at ...See full text at original site
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引用元：
https://doi.org/10.1016/s0960-0760(97)00120-9

データ提供：米国国立医学図書館（NLM）

Letrozole: A Potential Oasis in the Desert of Advanced Breast Cancer

Breast cancer, a formidable adversary, often presents unique challenges in treatment. This study delves into the effects of letrozole, an aromatase inhibitor, on advanced breast cancer. Think of letrozole as a cool breeze in the desert, potentially slowing down the growth of cancer cells. It's like finding a source of water in the midst of a dry and challenging landscape.

The researchers were intrigued by the potential of letrozole to influence the levels of IGF-I and IGFBP-3, two key molecules involved in cell growth and development. Imagine these molecules as desert plants, thriving in specific conditions. Letrozole, like a desert rain, may alter the growth of these plants, ultimately impacting the progression of breast cancer.

The study found that letrozole significantly increased the levels of IGF-I in patients with advanced breast cancer. This suggests that letrozole could potentially impact the growth and development of cancer cells. However, further research is needed to fully understand the implications of this finding.

Letrozole's Potential Role in Advanced Breast Cancer Treatment

This study suggests that letrozole may have a significant impact on advanced breast cancer. While further research is needed, it offers a glimmer of hope in the fight against this disease.

The Importance of Continued Research in Breast Cancer Treatment

This study is a testament to the ongoing efforts to find effective treatments for breast cancer. It encourages continued research to understand the intricate mechanisms of this disease and discover new ways to combat it.

Dr.Camel's Conclusion

Letrozole, a potential oasis in the desert of advanced breast cancer, shows promising results in its ability to influence key molecules involved in cancer growth. While further research is necessary, this study offers a ray of hope in the fight against this formidable disease.

Date :
  1. Date Completed 1998-02-18
  2. Date Revised 2019-08-31
Further Info :

Pubmed ID

9459192

DOI: Digital Object Identifier

10.1016/s0960-0760(97)00120-9

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Languages

English

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