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Increased lithium serum and red blood cell concentrations during ketorolac coadministration.
Author: AugustinB G, AwadE, ColdJ A, JannM W, SimpsonM A, ZumBrunnenT L
Original Abstract of the Article :
Case reports of a lithium-ketorolac drug interaction have been published, but no formal investigation of this interaction has been conducted. The objective of the study presented here was to determine significant changes in lithium serum and red blood cell (RBC) concentrations after lithium and keto...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1097/00004714-199802000-00006
データ提供:米国国立医学図書館(NLM)
A Drug Interaction to Watch Out For: Lithium and Ketorolac
In the world of pharmacology, drug interactions are like unexpected sandstorms in the desert—they can disrupt the intended course of treatment. This study investigates the potential interaction between lithium and ketorolac, two commonly prescribed medications. The researchers, like explorers venturing into uncharted territory, sought to determine whether coadministration of these drugs could lead to changes in lithium levels.
The results of this study revealed a significant interaction between lithium and ketorolac. The researchers observed a significant increase in both serum and red blood cell lithium concentrations when ketorolac was added to lithium therapy. This interaction could potentially lead to an increased risk of lithium-associated side effects, raising concerns about patient safety.
The Importance of Careful Monitoring
This research highlights the importance of careful monitoring for drug interactions, particularly when coadministering lithium and ketorolac. Just as a camel must navigate the desert with caution, healthcare professionals must be vigilant in assessing the potential risks of combining medications.
Ensuring Patient Safety
This study underscores the importance of patient safety in drug therapy. By understanding the potential interactions between medications, healthcare providers can make informed decisions that minimize the risk of adverse effects and optimize treatment outcomes for their patients.
Dr. Camel's Conclusion
This study is like a warning sign in the desert of drug interactions. It reveals the potential dangers of combining lithium and ketorolac, emphasizing the need for careful monitoring and proactive management to ensure patient safety. As a researcher who has seen the complexities of drug interactions, I am reminded of the importance of vigilance and informed decision-making in prescribing medications.
Date :
- Date Completed 1998-04-02
- Date Revised 2019-09-09
Further Info :
Related Literature
English
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