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Paper Details

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Paper Details

Treatment of refractory myositis: a randomized crossover study of two new cytotoxic regimens.

Author: AdamsE M, BurgessS H, GourleyM F, HicksJ E, LeffR L, MillerF W, PlotzP H, ShermanJ B, ThorntonB C, VillalbaL

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Oral methotrexate combined with azathioprine showed a trend toward greater benefit in patients with treatment-resistant myositis compared to intravenous methotrexate with leucovorin rescue. Both treatments showed effectiveness in some patients.

Paper Details　

Original Abstract of the Article :

OBJECTIVE: To assess the clinical usefulness of 2 novel therapies for treatment-resistant myositis. METHODS: Thirty patients with refractory myositis, of whom 25 had an inadequate or no response to previous cytotoxic therapy, were randomized to begin either a combination of weekly oral methotrexate...See full text at original site

Dr.Camel's Paper Summary Blog

in preparation

Date :

Date Completed 1998-04-14
Date Revised 2022-03-31

Further Info :

Pubmed ID

DOI: Digital Object Identifier

10.1002/1529-0131(199803)41:3<392::AID-ART3>3.0.CO;2-X

Related Literature

Article Analysis

・Effective treatment of myositis

SNS

PICO Info

in preparation

Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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