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[Genetic and environmental effects on neuromodulation and the antinociceptive effect of dextromethorphan].

Author: AllazA F, DayerP, DesmeulesJ, OestreicherM K, PiguetV

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Dextromethorphan and its metabolite dextrophan were found to have antinociceptive and neuromodulatory effects. The effects were heavily dependent on the cytochrome P450 2D6 phenotype (CYP2D6).
Paper Details　
Original Abstract of the Article :
Administration of NMDA antagonists leads to attenuation or disappearance of some symptoms of central sensitization, such as secondary hyperalgesia. However, the side effects of NMDA antagonists to a large extent counterbalance the expected benefits, thus preventing wide or prolonged use. Dextrometho...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/9540144

データ提供：米国国立医学図書館（NLM）

Dextromethorphan: A Promising Antinociceptive with Neuromodulatory Potential

Central sensitization, a phenomenon characterized by heightened sensitivity to pain, is a significant challenge in pain management. This study investigates the antinociceptive and neuromodulatory effects of dextromethorphan, a readily available and safe drug, in pain models.

The study examined the effects of dextromethorphan and its metabolite dextrophan in pain models using electrical stimulation for testing antinociceptive effects and capsaicin-induced hyperalgesia. The results revealed that dextromethorphan exhibited clear antinociceptive and neuromodulatory effects. These effects were found to be heavily influenced by the cytochrome P450 2D6 phenotype (CYP2D6), highlighting the importance of considering individual differences in drug metabolism.

Exploring the Potential of Dextromethorphan in Pain Management

This study suggests that dextromethorphan, a commonly available drug, possesses antinociceptive and neuromodulatory properties. Further research is needed to explore its potential as a therapeutic agent for managing chronic pain.

A Camel's Perspective: A Journey Through the Sands of Pain

Pain can be a debilitating experience, but finding safe and effective treatments can be like searching for a mirage in the desert. This study provides a glimmer of hope, suggesting that dextromethorphan may offer a novel approach to managing pain.

Dr. Camel's Conclusion

This study demonstrates the antinociceptive and neuromodulatory effects of dextromethorphan in pain models. Further research is warranted to explore its potential as a therapeutic agent for managing chronic pain, taking into account individual differences in drug metabolism.
Date :
  1. Date Completed 1998-05-21
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

9540144

DOI: Digital Object Identifier

9540144

SNS
PICO Info
in preparation
Languages

French

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