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Peroxisome-proliferating effects of fenoprofen in mice.

Author: De CraemerD, PauwelsM, VamecqJ, Van den BrandenC

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Fenoprofen, an arylpropionic acid, was found to be a peroxisome proliferator in the liver of mice. Treatment with fenoprofen led to a dose-dependent increase in peroxisomal enzymes, including palmitoyl-CoA oxidase, carnitine acyltransferase, and acyl-CoA hydrolase. These findings suggest that fenoprofen may have peroxisome-related effects in humans, but further research is needed.
Paper Details　
Original Abstract of the Article :
We report on hepatic effects obtained in vivo by treating mice with different doses of fenoprofen, an arylpropionic acid previously shown to inhibit in vitro peroxisomal very long chain fatty acid oxidation. A strong and dose-related induction of peroxisomal palmitoyl-CoA oxidase, and of carnitine a...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/9625603

データ提供：米国国立医学図書館（NLM）

Fenoprofen: A Peroxisome Proliferator in the Desert of Lipid Metabolism

Fenoprofen, a nonsteroidal anti-inflammatory drug (NSAID), has been shown to inhibit peroxisomal very long chain fatty acid oxidation in vitro. This research, like a journey through a desert of biochemical pathways, investigates the effects of fenoprofen on peroxisome proliferation in mice. The study, like a meticulous desert researcher, examines the impact of fenoprofen on various peroxisomal enzymes and the morphology of peroxisomes in the liver.

Fenoprofen: A Peroxisome Proliferator

The findings suggest that fenoprofen acts as a peroxisome proliferator in the liver of mice, leading to an increase in peroxisomal enzyme activity and changes in peroxisome morphology. It’s like finding a hidden oasis of activity in the desert of peroxisomal function. The study highlights the potential of fenoprofen to modulate peroxisome function, suggesting a complex interplay between this NSAID and lipid metabolism.

Navigating the Desert of Lipid Metabolism

This research underscores the complex interplay between NSAIDs and lipid metabolism. It’s like discovering a hidden network of pathways in the desert of lipid metabolism. The findings encourage further research to fully understand the impact of fenoprofen and other NSAIDs on peroxisomal function and the implications for human health.

Dr. Camel’s Conclusion

This research provides valuable insights into the effects of fenoprofen on peroxisome function in mice. It’s a reminder that the desert of lipid metabolism is a complex and dynamic landscape, with many hidden pathways and interactions to be explored.
Date :
  1. Date Completed 1998-07-30
  2. Date Revised 2018-03-19
Further Info :

Pubmed ID

9625603

DOI: Digital Object Identifier

9625603

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Article Analysis
・Effects of fenoprofen
SNS
PICO Info
in preparation
Languages

English

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