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Photosensitizing drugs containing the benzophenone chromophore.

Author: BoscáF, MirandaM A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Benzophenone-derived photosensitizing drugs, such as ketoprofen, tiaprofenic acid, suprofen, tolmetin, fenofibrate, and amiodarone, can cause phototoxic reactions upon exposure to sunlight. These drugs contain a diaryl ketone chromophore that mediates photosensitization.
Paper Details　
Original Abstract of the Article :
The nonsteroidal anti-inflammatory agents ketoprofen, tiaprofenic acid, suprofen and tolmetin, together with the anti-hyperlipoproteinemic drug fenofibrate and the anti-arrhythmic amiodarone can be included in the group of benzophenone-derived photosensitizing drugs. They contain a diaryl ketone chr...See full text at original site
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引用元：
https://doi.org/10.1016/s1011-1344(98)00062-1

データ提供：米国国立医学図書館（NLM）

Photosensitizing Drugs: The Hidden Dangers of Sunlight

Certain medications containing the benzophenone chromophore have been linked to photosensitization reactions, leading to adverse effects upon exposure to sunlight. This research examines the photosensitizing properties of various benzophenone-derived drugs, including ketoprofen, tiaprofenic acid, suprofen, tolmetin, fenofibrate, and amiodarone. The authors explore the mechanisms underlying these photosensitization reactions, providing insights into the potential risks associated with these medications.

The Sun's Shadow: Understanding Photosensitization

The study confirms that these benzophenone-derived drugs can mediate phototoxic and, in some cases, photoallergic reactions. The research highlights the importance of patient education and awareness regarding the potential for photosensitization when using these medications.

A Sun-Smart Approach: Minimizing Risks

This research underscores the need for caution when using benzophenone-derived drugs, particularly during sun exposure. Patients should be advised to limit their exposure to sunlight, wear protective clothing, and use sunscreen to minimize the risk of photosensitization reactions.

Dr. Camel's Conclusion

Just as a camel must seek shade to escape the scorching desert sun, individuals using benzophenone-derived medications need to be mindful of their sun exposure. This research sheds light on the potential dangers of these medications, reminding us to be vigilant in protecting our skin from the harmful effects of sunlight.

Date :
  1. Date Completed 1998-08-03
  2. Date Revised 2019-09-21
Further Info :

Pubmed ID

9639910

DOI: Digital Object Identifier

10.1016/s1011-1344(98)00062-1

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Languages

English

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