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Experimental study on the effects of gentamicin injection on the guinea-pig: electrophysiological studies.

Author: HottaS, ItohT, TakahashiM, YamamuraK

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Gentamicin, an aminoglycoside antibiotic, can cause inner ear damage. In guinea pigs, daily injections of gentamicin (60 mg/kg) led to decreased cochlear microphonics (CM) and compound action potential (CAP) amplitudes, suggesting damage to the cochlea and eighth cranial nerve. Additionally, endocochlear potential (EP) changes were observed during anoxia, indicating altered diffusion potentials within the inner ear.
Paper Details　
Original Abstract of the Article :
The inner ear distortion induced by gentamicin (GM), a type of aminoglycoside antibiotic, was examined in guinea-pigs. Previous studies which investigated the function of the eighth cranial nerve and organ of Corti using cochlear microphonics (CM) and compound action potential (CAP) reported ototoxi...See full text at original site
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引用元：
https://doi.org/10.1080/00016489850183449

データ提供：米国国立医学図書館（NLM）

Gentamicin and the Inner Ear: A Sandstorm in the Desert of Auditory Health

Gentamicin, a commonly used antibiotic, can sometimes have unexpected side effects, like a sandstorm sweeping across a delicate landscape. This study investigates the effects of gentamicin on the inner ear, specifically its impact on the organ of Corti and the eighth cranial nerve, which are responsible for hearing and balance.

The Sandstorm's Impact: Gentamicin and Inner Ear Damage

The researchers found that gentamicin injections could lead to significant damage to the inner ear, affecting various aspects of auditory function. It's like witnessing the destructive power of a sandstorm, eroding the delicate structures of the inner ear. This study underscores the importance of carefully considering the potential risks of gentamicin treatment, especially in relation to auditory health.

Protecting Auditory Health: Navigating the Desert of Inner Ear Function

This study emphasizes the importance of understanding the potential impact of gentamicin on the inner ear and taking precautions to protect auditory health. It's like having a guide to navigate the desert of inner ear function, recognizing the potential hazards and minimizing the risk of damage. The study's findings encourage healthcare professionals to carefully monitor patients receiving gentamicin treatment and consider alternative therapies if necessary.

Dr. Camel's Conclusion

This research explores the impact of gentamicin on the inner ear, highlighting the potential risks associated with its use. The study's findings emphasize the importance of careful monitoring and consideration of alternative therapies to protect auditory health.

Date :
  1. Date Completed 1998-10-06
  2. Date Revised 2019-07-16
Further Info :

Pubmed ID

9655210

DOI: Digital Object Identifier

10.1080/00016489850183449

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Article Analysis
・Effects of gentamicin injection
SNS
PICO Info
in preparation
Languages

English

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