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Involvement of dopamine receptors in diethylpropion-induced conditioning place preference.

Author: DeLuciaR, PlanetaC S

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Diethylpropion (DEP) showed reinforcing properties in rats, suggesting a potential for abuse. The reinforcing effect of DEP was mediated by dopamine D1 receptors.
Paper Details　
Original Abstract of the Article :
Diethylpropion (DEP) is an amphetamine-like agent used as an anorectic drug. Abuse of DEP has been reported and some restrictions of its use have been recently imposed. The conditioning place preference (CPP) paradigm was used to evaluate the reinforcing properties of DEP in adult male Wistar rats. ...See full text at original site
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引用元：
https://doi.org/10.1590/s0100-879x1998000400014

データ提供：米国国立医学図書館（NLM）

Investigating the Reinforcing Effects of Diethylpropion: A Focus on Dopamine Receptors

This research delves into the neurochemical mechanisms underlying the reinforcing properties of diethylpropion (DEP), an amphetamine-like drug used as an appetite suppressant. The study employs a conditioning place preference (CPP) paradigm to evaluate the rewarding effects of DEP in rats. The researchers investigated the role of dopamine receptors, particularly D1 and D2 receptors, in mediating these reinforcing effects.

Unveiling the Dopaminergic Mechanism of DEP

The study revealed that DEP produced a significant place preference in rats, suggesting its reinforcing properties. However, the study also found that blocking D1 receptors with SCH 23,390 abolished the DEP-induced CPP, while blocking D2 receptors with haloperidol had no effect. This indicates that dopamine D1 receptors play a crucial role in mediating the reinforcing effects of DEP. It's like navigating a desert with a compass, the D1 receptor acts as a key guide for the rewarding effects of DEP.

Implications for Understanding Drug Abuse

The study provides valuable insights into the neurochemical basis of DEP's rewarding effects, offering a deeper understanding of the mechanisms underlying drug abuse. This knowledge can help inform the development of strategies for preventing and treating substance abuse. Just like understanding the shifting sands of the desert helps us navigate its dangers, understanding the neurochemical pathways involved in drug addiction can guide us towards effective treatments.

Dr.Camel's Conclusion

This research sheds light on the intricate relationship between dopamine receptors and drug reinforcement. By understanding the neurochemical basis of drug abuse, we can develop more effective strategies for prevention and treatment. It's like deciphering the ancient secrets hidden within the dunes of the desert, leading us towards a better understanding of the human mind and its vulnerabilities.

Date :
  1. Date Completed 1998-10-06
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

9698810

DOI: Digital Object Identifier

10.1590/s0100-879x1998000400014

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SNS
PICO Info
in preparation
Languages

English

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