Efficacy of orally administered methylnaltrexone in decreasing subjective effects after intravenous morphine.

Author: FossJ F, MossJ, O'ConnorM, OsinskiJ, RoizenM F, YuanC S

Paper Details 
Original Abstract of the Article :
Opioid compounds are commonly used analgesics. After opioid administration, troublesome subjective effects, such as dysphoria, dizziness, nausea, and pruritus, have been reported. While some if not all of these are believed to occur due to central nervous system effects of opioids, the anecdotal rep...See full text at original site
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引用元:
https://doi.org/10.1016/s0376-8716(98)00087-8

データ提供:米国国立医学図書館(NLM)

Methylnaltrexone: A Potential Oasis for Opioid-Induced Side Effects

The use of opioids for pain relief is a double-edged sword, like a desert oasis that offers both refreshment and danger. While they effectively manage pain, opioids often come with undesirable side effects, such as nausea, itching, and dysphoria. This study, like a research expedition into this challenging terrain, investigates the potential of methylnaltrexone, a peripheral opioid receptor antagonist, to mitigate these side effects.

Researchers, much like intrepid explorers, conducted a double-blind, placebo-controlled study to evaluate the efficacy of oral methylnaltrexone. They found that methylnaltrexone, like a cooling breeze in the desert, effectively reduced nausea, itching, stimulation, and flushing associated with morphine administration.

Their findings, like a well-placed oasis, suggest that methylnaltrexone has potential therapeutic value in reducing these unwanted side effects, making opioid use a more comfortable experience for patients.

A More Comfortable Journey Through the Opioid Desert

The study findings, like a refreshing spring in the desert, offer hope for individuals who experience these uncomfortable side effects. Methylnaltrexone, like a reliable source of water, can help to mitigate these symptoms, making the journey through the opioid desert a little more comfortable.

Navigating the Opioid Desert: A Holistic Approach

While this study highlights the potential of methylnaltrexone, it's crucial to remember that a holistic approach to pain management, like navigating a desert with careful planning and preparation, is essential. This includes exploring alternative pain management strategies, optimizing opioid dosages, and addressing underlying medical conditions that might contribute to pain.

Dr.Camel's Conclusion

This study, like a caravan crossing a vast desert, takes us closer to understanding the complex terrain of opioid-induced side effects. The researchers, like seasoned explorers, have uncovered valuable insights into the potential of methylnaltrexone, offering a potential solution for reducing these unwanted symptoms. As we continue our journey through the desert of pain management, this study serves as a reminder of the importance of seeking effective treatments and improving the overall well-being of patients.

Date :
  1. Date Completed 1999-02-04
  2. Date Revised 2019-09-05
Further Info :

Pubmed ID

9800145

DOI: Digital Object Identifier

10.1016/s0376-8716(98)00087-8

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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