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The effect of lamotrigine on naloxone-precipitated opiate withdrawal.

Author: KostenT R, PearsallH R, RosenM I

Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Lamotrigine, a putative glutamate release antagonist, did not significantly attenuate any measure of opiate withdrawal in seven heroin-dependent subjects. Lamotrigine was well-tolerated, although one subject developed an allergic rash.
Paper Details　
Original Abstract of the Article :
We hypothesized that lamotrigine, a putative glutamate release antagonist, would attenuate glutamate-mediated signs of opiate withdrawal. Seven heroin-dependent subjects were hospitalized, stabilized on oral levorphanol 6 mg three times daily, and thrice underwent withdrawal precipitated by naloxone...See full text at original site
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引用元：
https://doi.org/10.1016/s0376-8716(98)00057-x

データ提供：米国国立医学図書館（NLM）

Lamotrigine and Opiate Withdrawal: A Challenging Journey

This research investigates the potential of lamotrigine, a medication used for epilepsy and bipolar disorder, to alleviate symptoms of opiate withdrawal. The study examines the effects of lamotrigine on naloxone-precipitated opiate withdrawal in heroin-dependent individuals. This research explores the potential for repurposing existing medications to manage the challenges of opiate withdrawal.

Navigating the Labyrinth of Opiate Withdrawal

The study found that lamotrigine did not significantly attenuate the symptoms of opiate withdrawal. This research highlights the complexity of managing opiate withdrawal and the need for further investigation into effective treatment options. Just as a camel navigates a labyrinth of sand dunes, researchers are seeking the right path to alleviate the suffering associated with opiate withdrawal.

Finding Effective Solutions for Opiate Withdrawal

This research underscores the importance of finding effective treatment options for opiate withdrawal. Just as a wise camel seeks out water sources to survive in the desert, we must find ways to alleviate the physical and psychological distress associated with opiate withdrawal. This research encourages further exploration of medications and therapies to improve the management of this challenging condition.

Dr.Camel's Conclusion

This research reminds us that finding effective treatments for opiate withdrawal is an ongoing journey. Just as a camel adapts its strategy to the changing desert landscape, researchers continue to seek new and improved ways to manage the challenges of opiate withdrawal. This research encourages continued exploration of medications and therapies to alleviate the suffering associated with this complex condition.

Date :
  1. Date Completed 1999-02-04
  2. Date Revised 2019-09-05
Further Info :

Pubmed ID

9800147

DOI: Digital Object Identifier

10.1016/s0376-8716(98)00057-x

Related Literature

Article Analysis
・Effects of levorphanol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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