Comparative mutagenic and genotoxic effects of three antimalarial drugs, chloroquine, primaquine and amodiaquine.

Author: ChatterjeeT, GiriA K, KhanK A, MuhkopadhyayA

Paper Details 
Original Abstract of the Article :
Comparative mutagenic and genotoxic effects of three antimalarial drugs, chloroquine, primaquine and amodiaquine, were assessed in the Ames mutagenicity assay (in strains TA97a, TA100, TA102 and TA104) and in vivo sister chromatid exchange (SCE) and chromosome aberration (CA) assays in bone marrow c...See full text at original site
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引用元:
https://doi.org/10.1093/mutage/13.6.619

データ提供:米国国立医学図書館(NLM)

Unveiling the Genotoxic Effects of Antimalarial Drugs

The study investigates the mutagenic and genotoxic effects of three commonly used antimalarial drugs: chloroquine, primaquine, and amodiaquine. The authors utilize both in vitro and in vivo assays to assess the potential risks associated with these drugs. The study revealed that all three drugs exhibited weak mutagenic effects in bacterial assays, but they were found to be genotoxic in mouse bone marrow cells. This research highlights the importance of considering the potential risks associated with antimalarial drugs while acknowledging their vital role in combating malaria.

Navigating the Desert of Drug Toxicity

This study delves into the complex world of drug toxicity, uncovering the potential hazards associated with commonly used antimalarial drugs. The researchers found that while these drugs may be effective in treating malaria, they also pose certain risks. It's like navigating a vast desert where hidden dangers lurk beneath the surface. The study emphasizes the need for careful consideration and ongoing monitoring of drug safety, particularly for antimalarial drugs.

Living With the Risks of Antimalarial Drugs

This study underscores the importance of working closely with healthcare professionals when using antimalarial drugs. Patients should discuss their medical history and any potential risks associated with these medications. It's crucial to be aware of the potential side effects and monitor your health closely while taking these drugs. Remember, just like a camel needs to be mindful of its surroundings in the desert, you need to be informed and proactive in managing your health.

Dr. Camel's Conclusion

This research provides valuable insights into the potential genotoxic effects of antimalarial drugs. While acknowledging the essential role of these drugs in combating malaria, the study emphasizes the need for careful consideration of drug safety. It's a reminder that even seemingly harmless substances can have unforeseen consequences. Just like a camel needs to be vigilant in the desert, we need to be cautious and mindful of the potential risks associated with medications.
Date :
  1. Date Completed 1999-02-25
  2. Date Revised 2019-05-12
Further Info :

Pubmed ID

9862194

DOI: Digital Object Identifier

10.1093/mutage/13.6.619

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English

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