Effects of choline magnesium trisalicylate: A Synthesis of Findings from 27 Studies

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Original Abstract of the Article

Major Research Findings

Choline magnesium trisalicylate (CMT) is a non-acetylated salicylate, a type of nonsteroidal anti-inflammatory drug (NSAID) often used to reduce inflammation symptoms such as joint pain and swelling. Several studies have shown CMT to be effective in reducing pain and improving joint swelling. For instance, 24 conducted a double-blind controlled study on 8 adult hemophilia patients, finding that both CMT and ibuprofen (IPF) were superior to placebo in relieving pain and stiffness. Additionally, 20 found that in a study on 23 patients with rheumatoid arthritis, CMT significantly reduced indices of inflammation. CMT is considered to be gentler on the stomach and have a lower risk of bleeding compared to aspirin. However, 14 reported a case of a 21-year-old woman who developed mild hepatotoxicity while receiving CMT therapy. Furthermore, 5 reported a case of severe hypersensitivity hepatitis with striking tissue and peripheral eosinophilia after ingestion of choline magnesium trisalicylate. Like other NSAIDs, CMT can cause side effects such as stomach upset, nausea, and indigestion. It is important to be aware of these potential side effects when taking CMT.

Benefits and Risks

Benefit Summary

CMT has the potential to reduce inflammation symptoms like joint pain and swelling. It is considered to be gentler on the stomach and have a lower risk of bleeding compared to aspirin. CMT may be beneficial for treating conditions like rheumatoid arthritis and hemophilia. However, similar to other NSAIDs, CMT can cause side effects such as stomach upset, nausea, and indigestion. It's important to be cautious of these potential side effects when using CMT. The reason why CMT is gentler on the stomach than aspirin is likely due to aspirin's stronger impact on the gastric mucosa. CMT is also considered to have a lower bleeding risk than aspirin, potentially due to its weaker inhibition of platelet aggregation. Overall, CMT has the potential to be a safer alternative to aspirin in treating pain and swelling, but always consult a doctor and take it as prescribed.

Risk Summary

CMT can cause side effects such as stomach upset, nausea, and indigestion. Furthermore, CMT could impact the liver, potentially leading to liver dysfunction. In rare cases, CMT may cause serious side effects like eosinophilic hepatitis. It is crucial to be aware of these potential side effects when using CMT. CMT should not be used by individuals with aspirin allergies or those at a high risk of bleeding. Always consult a doctor and take CMT as prescribed.

Comparison between Studies

Commonalities in Studies

Multiple studies have shown CMT to be effective in reducing pain and improving joint swelling. CMT is considered to be gentler on the stomach and have a lower risk of bleeding compared to aspirin. These studies suggest that CMT could be helpful in treating conditions like rheumatoid arthritis. However, all of these studies were relatively small, and more research is needed to understand the long-term effects and safety of CMT.

Differences in Studies

CMT's efficacy varies between studies. For example, 24 found CMT effective in relieving pain and stiffness, while 14 showed potential liver impact. These discrepancies could be attributed to factors such as the number of study participants and differences in research methods. Larger, longer-term studies are necessary to thoroughly understand CMT's effects. Given the potential liver impact of CMT, regular liver function tests are important for those taking it.

Consistency and Discrepancies in Results

The effects of CMT vary across studies. This variability might be linked to the size of the study population and differences in research methodologies. To gain a more comprehensive understanding of CMT's effects, larger and longer-term studies are crucial. Given the possibility of liver impact, regular liver function testing is essential for individuals taking CMT.

Considerations for Real-World Application

CMT may be beneficial in reducing inflammation symptoms like pain and swelling. However, potential side effects such as stomach upset, nausea, indigestion, and liver impact must be considered. CMT is not recommended for individuals with aspirin allergies or those at high risk of bleeding. Always consult a doctor and take CMT as prescribed.

Limitations of Current Research

Research on CMT's efficacy has been limited to small-scale studies, requiring further investigation for a comprehensive understanding of its long-term effects and safety. The discrepancies in findings across studies highlight the need for more extensive research. It is essential to explore the long-term effects and safety of CMT, as well as its impact on the liver, in future studies.

Future Research Directions

To gain a deeper understanding of CMT, larger and longer-term studies are needed. Future research should focus on investigating the long-term effects, safety, and liver impact of CMT. Additionally, research comparing the efficacy and safety of CMT with other NSAIDs is necessary.

Conclusion

CMT holds potential for reducing inflammation symptoms like pain and swelling. However, it is crucial to be aware of potential side effects, including stomach upset, nausea, indigestion, and liver impact. CMT is not suitable for those with aspirin allergies or at high risk of bleeding. Always consult a doctor and take CMT as prescribed. Further research is necessary to fully understand the long-term effects, safety, and liver impact of CMT.

Literature analysis of 27 papers
Positive Content
20
Neutral Content
2
Negative Content
5
Article Type
10
0
0
2
27
1.

Endoscopic evaluation of the comparative effects of acetylsalicylic acid and choline magnesium trisalicylate on human gastric and duodenal mucosa.

Author: KilanderA, DotevallG

Reduced mucosal lesions
Mucosal changes

Choline magnesium trisalicylate (Trilisate tablets) was found to be less damaging to the gastroduodenal mucosa than acetylsalicylic acid in equipotent doses. While acetylsalicylic acid caused multiple mucosal lesions in all participants, Trilisate only caused slight changes in four out of ten.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Nuclear factor-kappaB modulation in patients undergoing induction chemotherapy for acute myelogenous leukemia.

Author: StrairRoger K, GhariboMecide, SchaarDale, RubinArnold, HarrisonJonathan, AisnerJoseph, LinHsin-Ching, LinYong, GoodellLauri, AnandMonika, BalsaraBinaifer, DudekLiesel, RabsonArnold, MedinaDaniel J

This study aims to determine if standard anti-inflammatory agents modulate nuclear factor-kappaB (NF-kappaB) in acute myelogenous leukemia (AML) cells when administered with induction chemotherapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Adverse respiratory reactions to aspirin and nonsteroidal anti-inflammatory drugs.

Author: SimonRonald A

AERD treatment
Aspirin desensitization

Aspirin-exacerbated respiratory disease (AERD) is a chronic condition characterized by asthma, rhinosinusitis/nasal polyps, and sensitivity to aspirin and other cyclooxygenase-1 (COX-1) inhibitors. This review discusses the diagnosis, treatment, and management of AERD, including aspirin desensitization, which effectively reduces upper-airway mucosal congestion, nasal polyp formation, and systemic steroid requirements.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study.

Author: JohnsonJ R, MillerA J

Bone pain relief

Choline magnesium trisalicylate (CMT) significantly relieved bone pain caused by metastatic cancer in 26 patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Eosinophilic hepatitis after ingestion of choline magnesium trisalicylate.

Author: NadkarniM M, PellerC A, RetigJ

Widely used NSAID
Hypersensitivity hepatitis
Peripheral eosinophilia
Tissue eosinophilia

A case of severe hypersensitivity hepatitis with striking tissue and peripheral eosinophilia was reported following ingestion of choline magnesium trisalicylate, a non-acetylated salicylate.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

The effects of a salicylate, ibuprofen, and naproxen on the disposition of methotrexate in patients with rheumatoid arthritis.

Author: TracyT S, KrohnK, JonesD R, BradleyJ D, HallS D, BraterD C

Methotrexate dosage
NSAID toxicity

NSAIDs can affect the disposition of methotrexate, possibly increasing the potential for toxicity and necessitating dosage adjustments in patients with rheumatoid arthritis.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

7.

Salicylate pre-treatment attenuates intensity of bronchial and nasal symptoms precipitated by aspirin in aspirin-intolerant patients.

Author: NizankowskaE, DworskiR, SojaJ, SzczeklikA

Protection against asthma

Choline magnesium trisalicylate (CMT) offered moderate protection against aspirin-induced asthma in 9 patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Choline magnesium trisalicylate in patients with aspirin-induced asthma.

Author: SzczeklikA, NizankowskaE, DworskiR

Safe for asthmatics

Choline magnesium trisalicylate (CMT) was found to be well-tolerated in 23 asthmatics with aspirin hypersensitivity. CMT did not show any airway obstruction, nasal congestion, or rhinorrhea. The absence of cyclooxygenase inhibition with CMT was also confirmed by the lack of significant decrease in serum thromboxane B2 levels.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

A comparison of choline magnesium trisalicylate and acetylsalicylic acid in patients with rheumatoid arthritis.

Author: Le GallezP, BirdH A, WrightV

Side effects

Choline magnesium trisalicylate (3.0 g/day) and enteric-coated acetylsalicylic acid (3.0 g/day) were compared in a double-blind, crossover study in patients with rheumatoid arthritis. There was no significant clinical difference between the two treatments. There was also no clear difference in the side-effects profile, but the number of patients recruited was small.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Comparison of the effect of aspirin and choline magnesium trisalicylate on thromboxane biosynthesis in human platelets: role of the acetyl moiety.

Author: DaneshB J, McLarenM, RussellR I, LoweG D, ForbesC D

Safer than ASA

Choline magnesium trisalicylate (CMT), a non-acetylated salicylate, did not inhibit platelet thromboxane biosynthesis, unlike aspirin, suggesting it may be safer for therapeutic use.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Therapeutic potential of choline magnesium trisalicylate as an alternative to aspirin for patients with bleeding tendencies.

Author: DaneshB J, SaniabadiA R, RussellR I, LoweG D

The effects of acetyl salicylic acid (ASA, aspirin) and choline magnesium trisalicylate (CMT), a non-acetylated salicylate, on platelet aggregation were compared in human whole blood ex vivo. Although both drugs had comparable salicylic acid absorption, ASA significantly inhibited platelet aggregation induced by collagen, arachidonic acid, and spontaneously, while CMT did not. CMT may be a potential alternative to aspirin when platelet aggregation inhibition could lead to bleeding complications.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Serum concentrations of salicylate and naproxen during concurrent therapy in patients with rheumatoid arthritis.

Author: FurstD E, SarkissianE, BlockaK, CassellS, DromgooleS, HarrisE R, HirschbergJ M, JosephsonN, PaulusH E

Decreased naproxen levels

Salicylate decreased serum naproxen concentration and increased serum naproxen clearance, while naproxen had minimal effect on serum salicylate concentrations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

14.

Hepatotoxicity associated with choline magnesium trisalicylate: case report and review of salicylate-induced hepatotoxicity.

Author: CersosimoR J, MatthewsS J

Reduced fever
Hepatotoxicity

A 21-year-old woman developed mild hepatotoxicity while receiving choline magnesium trisalicylate therapy. After discontinuing the medication, the patient's liver function tests quickly returned to normal.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

15.

A controlled study of concurrent therapy with a nonacetylated salicylate and naproxen in rheumatoid arthritis.

Author: FurstD E, BlockaK, CassellS, HarrisE R, HirschbergJ M, JosephsonN, LachenbruchP A, TrimbleR B, PaulusH E

Rheumatoid arthritis treatment
Gastrointestinal complaints
Skin toxicity
Tinnitus

A combination of choline magnesium trisalicylate and naproxen was not significantly more effective than either drug alone in treating rheumatoid arthritis. However, the combination was associated with a higher incidence of side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

17.

Sensitivity to non-acetylated salicylates in a patient with asthma, nasal polyps, and rheumatoid arthritis.

Author: ChudwinD S, StrubM, GoldenH E, FreyC, RichmondG W, LuskinA T

Bronchial asthma
Bronchospastic reaction
Urticarial reaction

A patient with bronchial asthma was sensitive to non-acetylated salicylates, including choline magnesium trisalicylate, suggesting that non-acetylated salicylates may not be suitable for aspirin-sensitive patients.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

18.

Once-daily treatment of rheumatoid arthritis with choline magnesium trisalicylate.

Author: MannC C, BoyerJ T

Effective for rheumatoid arthritis

Once-daily treatment with choline magnesium trisalicylate (CMT) was as effective as twice-daily treatment in controlling rheumatoid arthritis symptoms. Side effects were similar in both regimens.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

The effect of the non-steroidal anti-inflammatory drug choline magnesium trisalicylate on gastric mucosal cell exfoliation.

Author: MitchellK G, HearnsJ, CreanG P

Gastric irritation
Increased bleeding
Nausea
Tinnitus

Both choline magnesium trisalicylate (CMT) and aspirin caused gastric mucosal cell exfoliation. However, CMT was associated with more side effects, including tinnitus, nausea, and increased faecal blood loss.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

20.

Clinical evaluation of choline magnesium trisalicylate in rheumatoid arthritis.

Author: ModyG M, NaidooP D, SinghT G

Improved indices of inflammation
Gastrointestinal side effects
Pruritus
Tinnitus

Choline magnesium trisalicylate (CMT) was effective in reducing inflammation in patients with rheumatoid arthritis. Tinnitus was the most common side effect, which resolved with dose reduction.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

Effect of choline magnesium trisalicylate on prostacyclin production by isolated vascular tissue of the rat.

Author: LevyJ V

Does not affect PGI2 production

Choline magnesium trisalicylate (Trilisate) did not affect the production of prostacyclin-like substance by rat aortic tissue at therapeutic concentrations. Its ED50 for inhibition was 1200 mg/100 ml, which is 40 times higher than the maximum therapeutic blood concentration in humans. These results suggest that Trilisate does not adversely affect blood vessel function at therapeutic doses.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

22.

Reduced faecal blood loss in patients receiving choline magnesium trisalicylate ('Trilisate') when compared with aspirin.

Author: WraightE P, SeamanM J

Reduced fecal blood loss
None reported

Choline magnesium trisalicylate and acetylsalicylic acid were compared for their effects on fecal blood loss. Choline magnesium trisalicylate caused significantly less fecal blood loss.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

Efficacy and safety of a non-acetylated salicylate, choline magnesium trisalicylate, in the treatment of rheumatoid arthritis.

Author: RothwellK G

Lower GI side effects
Similar or greater improvement

CMT showed similar or greater improvement in rheumatoid arthritis compared to ASA with fewer gastrointestinal side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

24.

Nonsteroidal anti-inflammatory drugs in the treatment of hemophilic arthropathy.

Author: ThomasP, HepburnB, KimH C, SaidiP

Treats hemophilic arthropathy
Bleeding time prolongation

Ibuprofen (IPF) and choline magnesium trisalicylate (CMT) were found to be effective in relieving pain and stiffness in hemophilic patients. In a double-blind controlled study involving 8 patients, both drugs were safe for most patients, with only one patient showing a negative response.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

25.

Choline magnesium trisalicylate does not impair platelet aggregation.

Author: StuartJ J, PiskoE J

No platelet aggregation interference

Choline magnesium trisalicylate, a drug used for treating arthritis, did not significantly interfere with blood platelet aggregation in a study of nine patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

26.

Choline magnesium trisalicylate versus ibuprofen in rheumatoid arthritis.

Author: EhrlichG E, MillerS B, ZeidersR S

CMT efficacy
IPF efficacy
CMT side effects
IPF side effects

Both CMT and ibuprofen were effective in treating rheumatoid arthritis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

27.

Clinical comparative evaluation of choline magnesium trisalicylate and acetylsalicylic acid in rheumatoid arthritis.

Author: BlechmanW J, LechnerB L

Lower side effect incidence
Reduced symptom severity

Choline magnesium trisalicylate is as effective as acetylsalicylic acid in treating rheumatoid arthritis but has a lower incidence of adverse side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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