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Effects of renal impairment on the disposition of orally administered enalapril, benazepril, and their active metabolites.
Author: ConcordetD, LarouteV, LefebvreH P, ToutainP L
Original Abstract of the Article :
The pharmacokinetics of benazepril, enalapril, and their active metabolites (benazeprilat and enalaprilat) were compared after a single administration of each product by the oral route at the recommended dosage (0.5 mg/kg for both drugs) in the dog before and after moderate experimental renal impair...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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引用元:
https://pubmed.ncbi.nlm.nih.gov/10052059
データ提供:米国国立医学図書館(NLM)
Navigating Renal Impairment: Drug Disposition and Renal Function
This study, like a camel caravan traversing a vast and challenging desert, investigates the impact of renal impairment on the pharmacokinetics of enalapril and benazepril, two medications used to treat high blood pressure. Renal impairment, a condition affecting kidney function, can significantly alter the body's ability to process medications. The study explores how renal impairment affects the absorption, distribution, metabolism, and excretion of these drugs, seeking to optimize drug therapy in patients with compromised kidney function. The researchers delve into the intricate mechanisms of drug disposition, seeking to ensure safe and effective medication use for patients with renal impairment.
Adapting Treatment Strategies: A Desert Oasis of Personalized Care
The study highlights the importance of adjusting medication dosages and treatment strategies for patients with renal impairment. It's like finding a hidden oasis in a vast desert, providing a source of personalized care for those with unique health challenges. The study's findings underscore the need for careful monitoring and individualized approaches to drug therapy in patients with renal impairment, ensuring safe and effective treatment outcomes.
A Journey Towards Health: Optimizing Medication for Kidney Health
The study emphasizes the importance of understanding the complex interplay between drug disposition and renal function. It's like a camel caravan carefully navigating a challenging desert terrain, seeking to ensure optimal medication use for those with kidney health concerns. The research highlights the need for individualized treatment approaches and careful monitoring to optimize drug therapy for patients with renal impairment, promoting overall health and well-being.
Dr. Camel's Conclusion
This study, like a well-equipped camel caravan traversing a challenging desert landscape, provides valuable insights into the impact of renal impairment on drug disposition. The research emphasizes the importance of individualized treatment approaches and careful monitoring to ensure safe and effective medication use for patients with compromised kidney function, promoting overall health and well-being.
Date :
- Date Completed 1999-05-24
- Date Revised 2016-10-18
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English
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