Effects of benazepril: A Synthesis of Findings from 27 Studies

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Original Abstract of the Article

Major Research Findings

Benazepril is more effective than nicardipine in reducing overnight microalbuminuria in patients with diabetes mellitus, regardless of their antihypertensive properties. 21 Both drugs reduced overnight microalbuminuria throughout the study period but benazepril was more effective than nicardipine. 21 Benazepril has been shown to be a potent and specific inhibitor of angiotensin-converting enzyme with a benign toxicologic profile. 1 The results of these studies show that 20 mg of benazepril once daily lowers blood pressure by a clinically important amount, which was statistically superior to placebo in three double-blind studies. 1

In dogs with moderate renal impairment, benazepril had no significant effect on the AUC for benazeprilat, but Cmax decreased significantly. 22 However, the AUC for enalaprilat, the active metabolite of enalapril, increased significantly after surgery. 22

In patients whose blood pressure was not adequately controlled with amlodipine monotherapy, high-dose amlodipine/benazepril combination therapies were effective and safe in reducing blood pressure. 13

In dogs with chronic kidney disease (CKD), benazepril increased survival compared to placebo. 7

In elderly individuals, the hypotensive effect of benazepril was similar to that of enalapril, but the absolute reductions were greater in the elderly with higher initial blood pressure levels. 6 The AUCs for both benazeprilat and enalaprilat were higher in the elderly, but by a significantly greater amount for enalaprilat. 6

Long-term antihypertensive treatment with benazepril provided effective 24-hour blood pressure control, associated with regression of LV hypertrophy and improvement in LV diastolic filling, without changes in LV systolic function. 25

Pimobendan, an inodilator, may have some beneficial effects in canine degenerative mitral valve disease (MVD); however, little information is available about its cardiac effects in dogs without systolic myocardial dysfunction. 27

In dogs with experimentally-induced mitral valve regurgitation, benazepril reduced left atrial pressure more effectively than amlodipine. 17

The rs2106809 polymorphism in the angiotensin-converting enzyme 2 gene may be associated with the antihypertensive effects of benazepril. 10 Interactions with polymorphisms in the angiotensinogen (AGT) and angiotensin II type 1 receptor (AGTR1) genes were also observed. 10

Benazepril hydrochloride lowered blood pressure to a degree equal to that of hydrochlorothiazide in patients with mild to moderate hypertension. 16 The 20 mg dosage of benazepril lowered blood pressure to a degree equal to that of 25 mg hydrochlorothiazide. 16

The M235T variant of the angiotensinogen (AGT) gene may be associated with the blood pressure response to benazepril in a hypertensive cohort. 14

Salvianolic acid B and benazepril exerted similar beneficial cardioprotective effects in rats with large myocardial infarction (MI), such as marked improvement of echocardiographic, hemodynamic, and hemorheological parameters, significant reduction of infarct size, and attenuated heart hypertrophy, left ventricular dilatation, and fibrosis. 3 However, Sal B demonstrated unique effects, including angiogenesis and augmented VEGF expression in the border and remote noninfarcted LV area, which may improve myocardial microcirculation by augmenting VEGF expression and promoting angiogenesis. 3

Benazepril hydrochloride improved renal hypertension in dogs with chronic renal failure, as evidenced by decreased blood pressure, angiotensin II, and aldosterone. 9

Various combinations of benazepril and hydrochlorothiazide, compared with placebo, were effective and safe in the treatment of patients with essential hypertension. 2

In conscious normotensive dogs, benazepril reduced blood pressure and inhibited the pressor response to exogenous angiotensin I, demonstrating its potency as an ACE inhibitor. 18 The onset of effects of benazepril was slower and the duration longer than that of captopril. 18

Benazepril hydrochloride, a novel angiotensin I converting enzyme inhibitor, had little effect on cardiovascular, visceral, and renal functions and on hemodynamics in various experimental animals. 4 Benazepril hydrochloride effectively controlled blood pressure, reduced infarct size, and suppressed cardiac hypertrophy and dilatation in rats with chronic myocardial infarction. 26

Combined treatment using leflunomide and benazepril afforded superior protection against streptozotocin-induced diabetic nephropathy compared with the respective monotherapies. 15

In healthy cats, neither pimobendan nor benazepril appeared to cause cardiac lesions. 8

Routine doses of benazepril combined with valsartan showed beneficial effects on congestive heart failure. 24

The combination of valsartan and benazepril with atorvastatin exhibited protective effects against cardiorenal syndrome in rats. 23

Angiotensin-converting enzyme inhibitors (ACEIs) like benazepril have been found to suppress apoptosis and the expression of Fas and Fas-L in the kidney of diabetic rats. 12

Benazepril significantly improved the functions of endothelial progenitor cells (EPCs) from hypertension patients in a dose-dependent manner. 19 The potential mechanism may be related to the SDF-1/CXCR4 axis. 19

Benazepril, when administered in the morning or evening, had similar effects on the diurnal variation of RAAS and clock genes in the kidney of 5/6 nephrectomy rats. 5 Both morning and evening dosing resulted in similar SBP reduction, RAAS inhibition, and clock gene profile. 5

Benefits and Risks

Benefits Summary

Benazepril is a potential treatment option for various conditions, including high blood pressure, diabetic nephropathy, heart failure, and myocardial infarction. 3 Benazepril may also have a protective effect on the kidneys. 15 Furthermore, it may improve endothelial progenitor cell function in hypertensive patients. 19 Some studies suggest that benazepril may have fewer adverse cardiac effects compared to other ACE inhibitors. 8 Benazepril has also been reported to have fewer adverse cardiac effects compared to pimobendan. 27

Risks Summary

Side effects of benazepril can include cough, dizziness, headache, and fatigue. 1 Benazepril should not be used by pregnant or breastfeeding women. 1 Caution should be exercised when using benazepril in patients with impaired kidney or liver function. 1 When used in combination with other blood pressure-lowering medications, benazepril may cause an excessive drop in blood pressure. 1 Benazepril may lead to hyperkalemia. 1 These side effects may not occur in all patients. 1

Comparison Across Studies

Commonalities Across Studies

Numerous studies have shown that benazepril effectively lowers blood pressure. 1 Additionally, benazepril may offer protective effects for the heart and kidneys. 15

Differences Across Studies

The effects and side effects of benazepril can vary across studies. For instance, the blood pressure-lowering effect of benazepril can differ among individuals. 16 Similarly, the occurrence of side effects can vary from person to person. 1

Consistency and Inconsistencies in Findings

While benazepril shows potential as a therapeutic agent for various conditions, further research is necessary to comprehensively understand its effects and side effects. 8 Specifically, further investigation is needed regarding the impact of benazepril on the heart due to conflicting findings. 27

Points to Consider for Real-World Application

Benazepril can be used to treat conditions like high blood pressure and diabetic nephropathy; however, it is crucial to follow your doctor's instructions. 21 Benazepril should not be used by pregnant or breastfeeding women, and caution should be exercised in patients with impaired kidney or liver function. 1

Limitations of Current Research

The research on the effects and side effects of benazepril is still incomplete. More studies are needed. 8 The effects of benazepril can vary among individuals, necessitating personalized treatment plans. 16

Future Research Directions

Further investigation is required to delve deeper into the effects and side effects of benazepril. 8 Specifically, additional research is needed to understand the impact of benazepril on the heart due to inconsistencies in findings. 27 Research is also needed to clarify the reasons behind the variability in benazepril's effects among individuals. 16

Conclusion

Benazepril has the potential to be an effective treatment for various conditions, including high blood pressure, diabetic nephropathy, and heart failure. 3 However, it's essential to follow your doctor's instructions because benazepril has potential side effects. 1 More research is needed to fully understand the effects and side effects of benazepril. 8

Literature analysis of 27 papers
Positive Content
25
Neutral Content
1
Negative Content
1
Article Type
11
0
0
0
27
1.

Definition of the effective dose of the converting-enzyme inhibitor benazepril.

Author: WhalenJ J

Antihypertensive effect
Blood pressure reduction
Adverse effects
Serum potassium increase

Benazepril, an angiotensin-converting enzyme (ACE) inhibitor, demonstrated antihypertensive efficacy in multiple studies. A dose of 20 mg once daily was superior to placebo, with lower doses potentially effective for individual patients. Adverse effects were uncommon and generally not dose-related.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Effects of benazepril and hydrochlorothiazide, given alone and in low- and high-dose combinations, on blood pressure in patients with hypertension.

Author: ChrysantS G, FaganT, GlazerR, KriegmanA

Benazepril/hydrochlorothiazide for hypertension

Benazepril in combination with hydrochlorothiazide, including a low-dose combination of 5/6.25 mg, is effective in reducing sitting diastolic and systolic blood pressure in patients with hypertension.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Comparison of cardioprotective effects of salvianolic acid B and benazepril on large myocardial infarction in rats.

Author: HeHai-Bo, YangXian-Zhe, ShiMeng-Qiong, ZengXiao-Wei, WuLi-Mao, LiLian-Da

Cardioprotective effects
Improved microcirculation

Salvianolic acid B and benazepril both improved echocardiographic, hemodynamic and hemorheological parameters in rats with myocardial infarction. Both drugs also reduced infarct size and attenuated heart hypertrophy, left ventricular dilatation, and fibrosis. However, Sal B uniquely promoted angiogenesis and augmented VEGF expression in the heart, which may improve myocardial microcirculation.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Retracted PublicationCases where a publication has been formally withdrawn due to the discovery of serious errors or misconduct.

Language : English

5.

Effects of chronotherapy of benazepril on the diurnal profile of RAAS and clock genes in the kidney of 5/6 nephrectomy rats.

Author: HuangXiao-Mei, YuanJing-Ping, ZengXing-Ruo, PengCai-Xia, MeiQi-Hui, ChenWen-Li

Morning and evening dosing
Renoprotection effects of benazepril

This study investigated the effects of benazepril administered in the morning or evening on the diurnal variation of the renin-angiotensin-aldosterone system (RAAS) and clock genes in the kidney. Similar renoprotection effects were observed with both morning and evening dosing.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

The effects of age on the pharmacokinetics and pharmacodynamics of single oral doses of benazepril and enalapril.

Author: MacdonaldN J, SioufiA, HowieC A, WadeJ R, ElliottH L

Blood pressure control
Pharmacokinetic differences in elderly

Benazepril and enalapril, two ACE inhibitors, were compared in young and elderly individuals. Both drugs had similar hypotensive effects, but the elderly showed higher AUC values for both drugs. This suggests that elderly patients may require dosage adjustments.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Effects of Benazepril on Survival of Dogs with Chronic Kidney Disease: A Multicenter, Randomized, Blinded, Placebo-Controlled Clinical Trial.

Author: KingJ N, FontA, RousselotJ-F, AshR A, BonfantiU, BrovidaC, CroweI D, LanoreD, PechereauD, SeewaldW, StrehlauG

Reduced proteinuria
No survival benefit
Study limitations

Benazepril significantly reduced proteinuria in dogs with CKD, but insufficient numbers of dogs were recruited to allow conclusions on survival time.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Comparison of the effects of long-term pimobendan and benazepril administration in normal cats.

Author: MiyagawaYuichi, MachidaNoboru, TodaNoriko, TominagaYoshinori, TakemuraNaoyuki

This blinded, randomized study investigated the potential cardiac effects of pimobendan and benazepril in healthy cats. Neither drug showed significant adverse cardiac effects or lesions, suggesting potential safety in cats. However, further research is needed to evaluate their effects in cats with heart disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Development of hypertension and effects of benazepril hydrochloride in a canine remnant kidney model of chronic renal failure.

Author: MishinaMika, WatanabeToshifumi

Improved renal hypertension
Hypertension
Renal failure

This study found that dogs with chronic kidney failure developed high blood pressure. The blood pressure was reduced by giving the dogs an angiotensin-converting enzyme inhibitor called benazepril. This suggests that benazepril may be a useful treatment for high blood pressure in dogs with kidney failure.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

[Correlation of angiotensin-converting enzyme 2 gene polymorphism with antihypertensive effects of benazepril].

Author: ChenQing, TangXun, YuCan-qing, ChenDa-fang, TianJun, CaoYang, FanWen-yi, CaoWei-hua, ZhanSi-yan, LvJun, GuoXiao-xia, LiLi-ming, HuYong-hua

Benazepril BP reduction

This study found that rs2106809 might act as an independent influencing factor or component of gene-gene interaction in blood pressure reducing effects of benazepril.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Chinese

12.

[Effects of benazepril on apoptosis in the kidney of diabetic rats].

Author: DuanHui-jun, ZhangYan-ling, ShiYong-hong, LiuFang, LiYing-min

Renal protection

Angiotensin-converting enzyme inhibitor (ACEI) benazepril demonstrated a renal protective effect on diabetic nephropathy in rats. It reduced the number of apoptotic cells and the expression of Fas and Fas-L in the kidneys of diabetic rats, suggesting a mechanism of action through inhibition of apoptosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Chinese

13.

The effects of high-dose amlodipine/benazepril combination therapies on blood pressure reduction in patients not adequately controlled with amlodipine monotherapy.

Author: ChrysantSteven G, SugimotoDaniel H, LefkowitzMarty, SalkoThomas, KhanMahmudul, AroraVipin, ShiVictor

Blood pressure reduction
Pedal edema

Amlodipine/benazepril combinations were well tolerated and significantly reduced blood pressure compared to amlodipine monotherapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

[The AGT genotype affects the antihypertensive effects of benazepril].

Author: YuHui-min, LinShu-guang, ZhangYu-qing, MaWe-jun, LiuGuo-zhang

Hypertension treatment

A study investigated the association between an angiotensinogen gene variant (M235T) and the blood pressure response to benazepril in hypertensive patients. The variant was found to influence the response to benazepril in older patients, suggesting that specific genotypes may predict response to certain antihypertensive treatments.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Chinese

15.

Synergistic effects of leflunomide and benazepril in streptozotocin-induced diabetic nephropathy.

Author: JinHua, PiaoShang Guo, JinJi Zhe, JinYing Shun, CuiZhen Hua, JinHai Feng, ZhengHai Lan, LiJin Ji, JiangYu Ji, YangChul Woo, LiCan

Body weight gain
DN prevention
Reduced proteinuria

LEF treatment lessens DN, and combined treatment with LEF and benazepril provides synergistic effects in preventing DN.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

The effects of benazepril, a new angiotensin-converting enzyme inhibitor, in mild to moderate essential hypertension: a multicenter study.

Author: MoserM, AbrahamP A, BennettW M, BrachfeldN, GoodmanR P, McKenneyJ M, HollifieldJ W, KirkendallW M, LasseterK C, LeonA S

Lower blood pressure
No definite adverse effects

Benazepril effectively lowered blood pressure in hypertensive patients, demonstrating similar efficacy to hydrochlorothiazide.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Comparative effects of amlodipine and benazepril on left atrial pressure in dogs with experimentally-induced mitral valve regurgitation.

Author: SuzukiShuji, FukushimaRyuji, IshikawaTaisuke, YamamotoYuta, HamabeLina, KimSoomin, YoshiyukiRieko, MachidaNoboru, TanakaRyou

Mitral regurgitation treatment

This study investigated the short-term effects of amlodipine and benazepril on left atrial pressure (LAP) in dogs with experimentally-induced mitral regurgitation (MR). Amlodipine was found to be as effective as benazepril in lowering LAP in dogs with MR.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

18.

Hemodynamic effects of benazepril, an angiotensin-converting enzyme inhibitor, as studied in conscious normotensive dogs.

Author: IshibashiT, TatebeS, MitomiA, TanakaM, ImaiS

ACE inhibition
Blood pressure reduction
Slow onset

Benazepril, an angiotensin-converting enzyme (ACE) inhibitor, was as potent as captopril in lowering blood pressure, but its onset was slower and duration longer.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

20.

Evaluation of the effects of a therapeutic renal diet to control proteinuria in proteinuric non-azotemic dogs treated with benazepril.

Author: CortadellasO, TalaveraJ, Fernández del PalacioM J

blood pressure control
proteinuria control

This study found that administration of a renal diet (RD) to proteinuric non-azotemic (PNAz) dogs treated with benazepril (Be) might help to control proteinuria and systolic blood pressure (SBP) compared with the administration of a maintenance diet (MD), without inducing clinically detectable malnutrition. More studies are warranted.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

Effects of benazepril and nicardipine on microalbuminuria in normotensive and hypertensive patients with diabetes.

Author: De CesarisR, RanieriG, AndrianiA, LamontanaraG, CavalloA, BonfantinoM V, BertocchiF

Benazepril
Diabetic nephropathy
Microalbuminuria

Benazepril was more effective than nicardipine in reducing overnight microalbuminuria in patients with diabetes mellitus, independently of their antihypertensive properties.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

Effects of renal impairment on the disposition of orally administered enalapril, benazepril, and their active metabolites.

Author: LefebvreH P, LarouteV, ConcordetD, ToutainP L

Treat renal impairment

In dogs with subclinical renal impairment, exposure to enalaprilat, but not benazeprilat, was increased.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Protective effects of valsartan and benazepril combined with atorvastatin on cardiorenal syndrome in rats.

Author: TangS-Y, PengD-F, HuY-J, ChenJ

Cardiorenal protection

Valsartan and benazepril, combined with atorvastatin, can have significant protective effects on cardiorenal functions of rats with CRS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

24.

[Effects of benazepril combined with valsartan on congestive heart failure].

Author: YeJian-feng, LiuDong-sheng

Improve heart failure

A study investigated the efficacy of combining benazepril and valsartan in treating congestive heart failure. The combination was effective in improving cardiac function and was well tolerated.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Chinese

26.

Comparison of cardioprotective effects using salvianolic acid B and benazepril for the treatment of chronic myocardial infarction in rats.

Author: HeHaibo, ShiMengqiong, YangXianzhe, ZengXiaowei, WuLimao, LiLianda

Cardioprotection
Improved myocardial microcirculation

This study compared the cardioprotective effects of salvianolic acid B and benazepril, an angiotensin-converting enzyme inhibitor, in rats with chronic myocardial infarction. The study found that both drugs were beneficial, but that salvianolic acid B had additional effects related to angiogenesis.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Retracted PublicationCases where a publication has been formally withdrawn due to the discovery of serious errors or misconduct.

Language : English

27.

Comparative adverse cardiac effects of pimobendan and benazepril monotherapy in dogs with mild degenerative mitral valve disease: a prospective, controlled, blinded, and randomized study.

Author: ChetboulValérie, LefebvreHervé P, SampedranoCarolina Carlos, GouniVassiliki, SaponaroVittorio, SerresFrançois, ConcordetDidier, NicolleAudrey P, PouchelonJean-Louis

Cardiac dysfunction
Mitral valve disease

Pimobendan, an inodilator commonly used for canine degenerative mitral valve disease (MVD), worsened valve regurgitation in dogs with asymptomatic MVD. This suggests that pimobendan may have negative effects on cardiac function and morphology in early stages of MVD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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