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Adjuvant hormonal treatment with radiotherapy for locally advanced prostate cancer.

Author: BollaM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Androgen suppression prior to and during radiation improves disease-free survival; adjuvant hormonal therapy with an LH-RHa during and after radiation improves overall survival. In three randomized phase III trials, a gain in disease-free, local relapse-free and metastasis-free survival was obtained.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: Long-term results of radiotherapy in locally advanced prostate cancer are poor due to local and distant failures. Since prostate cancer is hormone dependent, tumor androgen deprivation may enhance tumor eradication. METHODS: Three randomized phase III trials, RTOG and EORTC are reported...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/10081699

データ提供：米国国立医学図書館（NLM）

Adjuvant Hormonal Treatment with Radiotherapy for Prostate Cancer

This study investigates the effectiveness of combining androgen suppression with radiotherapy in treating locally advanced prostate cancer. This research addresses a critical challenge in the field of oncology, specifically the need for more effective treatment strategies for locally advanced prostate cancer, a challenging condition to manage. The researchers reviewed three randomized phase III trials evaluating the use of luteinizing hormone-releasing hormone analogues (LH-RHa) with or without androgen blockade in conjunction with radiotherapy. They found that [key finding] which highlights the potential benefits of adjuvant hormonal therapy in improving survival outcomes for patients with locally advanced prostate cancer.

Hormonal Therapy and Radiotherapy: A Powerful Combination

This research underscores the potential benefits of combining hormonal therapy with radiotherapy in the management of locally advanced prostate cancer. The researchers found that [specific numerical result], suggesting that this combination therapy can improve survival outcomes. This finding emphasizes the importance of considering adjuvant hormonal therapy as a valuable tool in the treatment of locally advanced prostate cancer.

A New Approach to Prostate Cancer Treatment

This study presents a new approach to prostate cancer treatment, highlighting the potential benefits of combining hormonal therapy with radiotherapy. The study's findings suggest that this combined approach can improve survival outcomes for patients with locally advanced prostate cancer. This research encourages further exploration of the role of adjuvant hormonal therapy in prostate cancer management.

Dr.Camel's Conclusion

Think of prostate cancer as a stubborn desert sandstorm, difficult to control. This study suggests that combining hormonal therapy with radiotherapy is like creating a powerful wind barrier, helping to contain the storm and improve patient outcomes. This research highlights the importance of combining different treatment modalities to effectively combat the challenges of prostate cancer.

Date :
  1. Date Completed 1999-07-22
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

10081699

DOI: Digital Object Identifier

eur5a023

Related Literature

Article Analysis
・Effective treatment of prostate cancer
SNS
PICO Info
in preparation
Languages

English

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