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Raloxifene hydrochloride, a selective estrogen receptor modulator: safety assessment of effects on cognitive function and mood in postmenopausal women.
Author: CoxD A, CrookT H, LufkinE G, NickelsenT, RiggsB L
Original Abstract of the Article :
Raloxifene hydrochloride (HCl) is a selective estrogen receptor modulator with estrogen agonist effects on bone and lipid metabolism and estrogen antagonist effects on reproductive tissues. Animal studies suggest that raloxifene may affect brain function as well, although the effects of raloxifene o...See full text at original site
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引用元:
https://doi.org/10.1016/s0306-4530(98)00041-9
データ提供:米国国立医学図書館(NLM)
Raloxifene and the Brain: Exploring Its Impact on Cognition and Mood
Raloxifene, a selective estrogen receptor modulator (SERM), is a familiar name in the realm of osteoporosis treatment. Its effects on bone and lipid metabolism are well-documented. However, the impact of raloxifene on the brain, that intricate and often mysterious organ, has been a topic of much speculation. This study, published in the journal [Journal Name], sets out to investigate the potential cognitive and mood effects of raloxifene in postmenopausal women.
The study employed a randomized, double-blind, placebo-controlled design, a powerful tool for minimizing bias and ensuring the reliability of the findings. Postmenopausal women participating in an osteoporosis treatment trial were randomly assigned to receive either raloxifene (60 or 120 mg/day) or a placebo. Their cognitive function was assessed using a battery of psychometric tests, while their mood was evaluated using the Geriatric Depression Scale.
The results, like a shimmering oasis in the vast desert of uncertainty, showed no significant differences between the raloxifene groups and placebo in terms of cognitive performance or mood after 12 months of treatment. This finding provides reassurance about the safety of raloxifene in terms of its cognitive and mood effects in postmenopausal women.
Raloxifene: A Safe and Effective Treatment for Osteoporosis
This research, like a clear path through the desert, offers reassurance that raloxifene, when used for osteoporosis treatment, does not appear to negatively impact cognitive function or mood in postmenopausal women. It is a valuable tool for maintaining bone health while minimizing the risk of adverse cognitive or mood effects.
Navigating the Desert of Osteoporosis with Raloxifene
For those seeking to navigate the challenges of osteoporosis, raloxifene provides a safe and effective option. Its positive effects on bone health, combined with the reassuring absence of negative cognitive or mood effects, make it a valuable tool for maintaining bone strength and overall well-being.
Dr.Camel's Conclusion
This research, like a beacon in the desert, offers valuable insights into the safety of raloxifene. While it's reassuring that raloxifene doesn't appear to negatively impact cognitive function or mood, ongoing research will continue to shed light on its potential effects on the brain.
Date :
- Date Completed 1999-07-06
- Date Revised 2022-02-23
Further Info :
Related Literature
English
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